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Immunomodulatory and therapeutic properties of alkyl lysophospholipids in mice

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Lipids

Abstract

This paper describes the immunomodulatory and therapeutic properties of the alkyl lysophospholipids [ALP; 1-O-octadecyl-2-O-rac-glycero-3-phosphocholine (ET-18-OCH3)]. ALP was able to activate macrophages both in vitro and in vivo as well as to act as an immunoadjuvant for syngeneic tumor vaccines. However, ALP appeared to be transferred, at least in part, to the macrophage membrane, and some of the tumoricidal macrophage-activating properties seem to be associated with the direct cytotoxic effect of membrane-released ALP. ALP also had some therapeutic activity for experimental and spontaneous metastases, requiring administration three but not two times weekly at near-toxic doses; this suggests that at least some of its therapeutic activity is due to direct cytotoxicity.

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Abbreviations

ALP:

alkyl lysophospholipids

BRM:

biological response modifiers

poly (I,C)-LC:

polyinosinic-polycytidylic acid complexed with poly-L-lysine and carboxymethylcellulose

MLR:

mixed lymphocyte reaction

MLTR-CMC:

mixed lymphocyte tumor response-cell-mediated cytotoxicity

HBSS:

Hanks’ balanced salts solution

NK:

natural killer

MTD:

maximum tolerated dose

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Authors and Affiliations

  1. Preclinical Screening Laboratory, Program Resources, Inc., National Cancer Institute-Frederick Cancer Research Facility, Frederick, Maryland

    James E. Talmadge, Mark Schneider, Barbara Lenz & Hamblin Phillips

  2. National Cancer Institute-Frederick Cancer Research Facility, Frederick, Maryland

    Cedric Long

Authors
  1. James E. Talmadge
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  2. Mark Schneider
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  3. Barbara Lenz
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  4. Hamblin Phillips
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  5. Cedric Long
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Talmadge, J.E., Schneider, M., Lenz, B. et al. Immunomodulatory and therapeutic properties of alkyl lysophospholipids in mice. Lipids 22, 871–877 (1987). https://doi.org/10.1007/BF02535547

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  • DOI: https://doi.org/10.1007/BF02535547

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