Skip to main content
SpringerLink
Log in

Intestinal absorption and fecal excretion of 5,6α-epoxy-5α-cholesta-3β-ol by the male wistar rat

  • Articles
  • Published:
Lipids

Abstract

The intestinal absorption of 5,6α-epoxy-5α-cholesta-3β-ol, an oxysterol formed by cholesterol autoxidation, has been evaluated in the male Wistar rat. Measurement of the14C/3H ratio in the serum (by the method of Zilversmit and Hugues) and in the feces showed that a large proportion of the epoxide was absorbed. Epoxide clearance from the blood was very rapid, but its excretion in the stool continued for several days, corresponding to the fraction of the epoxide stored in the animal.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Zilversmit, D.B., and Hugues, L.B. (1974)J. Lipid Res. 15, 465–473.

    PubMed  CAS  Google Scholar 

  2. Smith, L.L. (1981) inCholesterol Autoxidation, (Smith, L.L., ed.) pp. 41–119, Plenum Press, New York and London.

    Google Scholar 

  3. Anonymous (1980)Lancet 1, 964–965.

  4. Imaï, H., Werthessen, N.T., Subramanyan, V., Lesquesne, P.W., Soloway, A.H., and Kanisawa, M. (1980)Science 207, 651–653.

    Article  PubMed  Google Scholar 

  5. Taylor, C.B., Peng, S.K., Hill, J.C., and Mikkelson, B. (1980)Fed. Proc. 39, 771.

    Google Scholar 

  6. Penk, S.K., Taylor, C.B., Tham, P., Werthessen, N.T., and Mikkelson, B. (1978)Arch. Pathol. Lab. Med. 102, 57–61.

    Google Scholar 

  7. Smith, L.L., Smart, V.B., and Ansari, G.A.S. (1979)Mut. Res. 68, 23–31.

    Article  CAS  Google Scholar 

  8. Ansari, G.A.S., Walker, R.D., Smart, V.B., and Smith, L.L. (1982)Fed. Chem. Toxic. 20, 35–41.

    Article  CAS  Google Scholar 

  9. Benditt, E.P. (1977)Am. J. Path. 86, 693–698.

    PubMed  CAS  Google Scholar 

  10. Smith, L.L. (1981) inCholesterol Autoxidation (Smith, L.L., ed.) pp. 390–421, Plenum Press, New York and London.

    Google Scholar 

  11. Gryglewski, R.J. (1980) inVth, International Symposium on Atherosclerosis (Gotto, A.M., Smith, L.C., and Allen, B., eds.) pp. 762–770, Springer Verlag, New York, Heidelberg and Berlin.

    Google Scholar 

  12. Korahani, V., Bascoul, J., and Crastes de Paulet, A. (1982)Lipids 17, 703–708.

    CAS  Google Scholar 

  13. Gray, M.F., Lawrie, T.D.V., and Brooks, C.J.W. (1971)Lipids 6, 836–843.

    Article  PubMed  CAS  Google Scholar 

  14. Brooks, C.S.W., McKenna, R.M., Cole, W.J., mcLachlan, J., and Lawrie, T.D.V. (1983)Biochem. Soc. Trans. 11, 700–701.

    CAS  Google Scholar 

  15. Djerassi, C. (1963) inSteroids Reactions (Djerassi, C., ed.) pp. 395–651, Holden Day, San Francisco.

    Google Scholar 

  16. Fredrickson, D.S., and Ono, K. (1956)Biochim. Biophys. Acta 22, 183–184.

    Article  PubMed  CAS  Google Scholar 

  17. Bascoul, J., Domergue N., and Crastes de Paulet A. (1983)J. Steroid Biochim. 19, 1773–1782.

    Google Scholar 

  18. Peng, S.K., Taylor, C.B., Mosbach, E.H., Huang, W.Y., Hill, J., and Mikkelson, B. (1982)Atherosclerosis 41, 395–402.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Unité de Recherche sur la Biochimie des Stéroides, INSERM U. 58, 60 rue de Navacelles, 34100, Montpellier, France

    J. Bascoul, N. Domergue & A. Crastes de Paulet

  2. Centre de Nutrition Humaine, Université de Nancy, 40 rue Lionnois, 54000, Nancy, France

    J. Mourot & G. Debry

Authors
  1. J. Bascoul
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. Domergue
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. Mourot
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G. Debry
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. Crastes de Paulet
    View author publications

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

Bascoul, J., Domergue, N., Mourot, J. et al. Intestinal absorption and fecal excretion of 5,6α-epoxy-5α-cholesta-3β-ol by the male wistar rat. Lipids 21, 744–747 (1986). https://doi.org/10.1007/BF02535405

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02535405

Keywords

Search

Navigation