Skip to main content
SpringerLink
Log in

Gas chromatographic assay of the diastereomeric composition ofall-rac-α-tocopheryl acetate

  • Published:
Lipids

Abstract

It has been established by an evaluation of 6 production samples ofall-rac-α-tocopheryl acetate that all 4 racemates (RRS/SSR, RRR/SSS, RSR/SRS and RSS/SRR) are consistently present in equimolar amounts (SD<0.3, RSD<1.2%). An analysis of variance indicated variance due to signal noise to be consistent within a sample run but to vary from day to day. Variance due to area measurement was greater for the first and last eluted racemates than for the second and third. Peak width and asymmetry were found to be extremely sensitive to sample loading and, even within acceptable limits for good quantitation, the distortion was sufficient to give the elution profile the appearance of a sample composed of 4 components in unequal proportions increasing according to the order of elution.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Slover, H.T., and Thompson, R.H. (1981) Lipids 16, 268–275.

    CAS  Google Scholar 

  2. Cohen, N., Scott, C.G., Neukom, C., Lopresti, R.J., Weber, G., and Saucy, G. (1981) Helv. Chim. Acta 64, 1158–1173.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Chemical Research Department, Hoffmann-La Roche Inc., 07110, Nutley, NJ

    Clifford G. Scott, Noal Cohen, Patrick P. Riggio & Giuseppe Weber

Authors
  1. Clifford G. Scott
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Noal Cohen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Patrick P. Riggio
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Giuseppe Weber
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Dedicated to the memory of Dr. Willy Leimgruber, who died July 8, 1981.

About this article

Cite this article

Scott, C.G., Cohen, N., Riggio, P.P. et al. Gas chromatographic assay of the diastereomeric composition ofall-rac-α-tocopheryl acetate. Lipids 17, 97–101 (1982). https://doi.org/10.1007/BF02535182

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02535182

Keywords

Search

Navigation