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Effects of dietary 9-trans, 12-trans linoleate on arachidonic acid metabolism in rat platelets

  • Published:
Lipids

An Erratum to this article was published on 01 May 1982

Abstract

In order to determine the minimal amount of dietary 9-trans,12-trans-linoleate which can decrease endoperoxide metabolites synthesized and their precursor in rat platelets, graded amounts (0, 0.1, 0.5, 1.0, 2.5%) of thetrans-linoleate were fed to rats with a constant amount of all-cis-linoleate (2.5%) for 12 weeks. Arachidonic acid levels in platelet phospholipids of groups receiving thetrans-linoleate at 2.5 and 1.0% were significantly (p<0.01) lower than that of the control receiving notrans-linoleate. Concentrations of TXB2 and PGF2α in sera of the group receiving 2.5%trans-linoleate were significantly (p<0.05) lower than those of the control; however, there was no difference between the group receiving 1.0%trans-linoleate and the control. To determine whether the difference in serum concentrations of endoperoxide metabolites could be manifested if rats were fed for longer period of time, 2 groups of rats were again fed diets containing 0 and 1.0%trans-linoleate, respectively, for 16 weeks. Arachidonic acid in platelet phospholipids of the group receiving thetrans-linoleate was again significantly (p<0.01) lower than that of the control group. Concentrations of TXB2 and PGF2α, and 12-hydroxyeicosatetraenoic acid formed in platelets, were smaller in the group receivingtrans-linoleate than the control group; however, the difference was not statistically significant. These results indicated that all-trans-linoleate can reduce arachidonic acid metabolites formed in rat platelets when its dietary level is equal to or exceeds the level of all-cis-linoeate.

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Authors and Affiliations

  1. Louisiana Agricultural Experiment Station, Human Nutrition, Home Economics Building, Louisiana State University, 70803, Baton Rouge, LA

    D. H. Hwang, P. Chanmugam & R. Anding

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  1. D. H. Hwang
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  2. P. Chanmugam
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  3. R. Anding
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Additional information

An erratum to this article is available at http://dx.doi.org/10.1007/BF02535202.

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Hwang, D.H., Chanmugam, P. & Anding, R. Effects of dietary 9-trans, 12-trans linoleate on arachidonic acid metabolism in rat platelets. Lipids 17, 307–313 (1982). https://doi.org/10.1007/BF02534946

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  • DOI: https://doi.org/10.1007/BF02534946

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