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Effects of high fat diets on the activity of palmitoyl-CoA hydrolase in rat liver

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Lipids

Abstract

Palmitoyl-CoA hydrolase [EC 3.1.2.2.] activity in rat liver was found to be enhanced by high fat diets. Partially hydrogenated marine oil and high-erucic acid rapeseed oil diets produced a greater increase than a diet containing soybean oil.

With diets containing from 5 to 30% (w/w) of partially hydrogenated marine oil the increase in palmitoyl-CoA hydrolase activity was similar to the increase observed in peroxisomal β-oxidation activity (correlation coefficient r=0.94). A positive correlation (r=0.86) also was observed between the activity of palmitoyl-CoA hydrolase and previously determined levels of long-chain acyl-CoA.

The results presented may suggest a common “induction” mechanism for palmitoyl-CoA hydrolase and peroxisomal β-oxidation enzymes, possibly exerted through an increased cellular level of long-chain acyl-CoA.

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References

  1. Berge, R.K., and Bakke, O.M. (1981) Biochem. Pharmac. 30, 2251–2256.

    Article  CAS  Google Scholar 

  2. Berge, R.K., Skrede, S., and Farstad, M. (1981) FEBS Lett. 124, 43–47.

    Article  PubMed  CAS  Google Scholar 

  3. Berge, R.K., Aarsland, A., Bakke, O.M., and Farstad, M. (1983) Int. J. Biochem. 15, 191–204.

    Article  PubMed  CAS  Google Scholar 

  4. Berge, R.K., Flatmark, T., and Osmundsen, H. (1983). Submitted for publication in Eur. J. Biochem.

  5. Bakke, O.M., and Berge, R.K. (1982) Biochem. Pharmac. 31, 3930–3933.

    Article  CAS  Google Scholar 

  6. Berge, R.K., and Farstad, M. (1979) Eur. J. Biochem. 95, 89–97.

    Article  PubMed  CAS  Google Scholar 

  7. Berge, R.K., Osmundsen, H., Aarsland, A., and Farstad, M. (1982) Int. J. Biochem. 15, 205–209.

    Article  Google Scholar 

  8. Thomassen, M.S., Christiansen, E.N., and Norum, K.R. (1982) Biochem. J. 206, 195–202.

    PubMed  CAS  Google Scholar 

  9. Ishii, H., Fukumori, N., Horie, S., and Suga, T. (1980) Biochim. Biophys. Acta 617, 1–11.

    PubMed  CAS  Google Scholar 

  10. Neat, C.E., Thomassen, M.S., and Osmundsen, H. (1980) Biochem. J. 186, 369–371.

    PubMed  CAS  Google Scholar 

  11. Neat, C.E., Thomassen, M.S., and Osmundsen, H. (1980) Biochem. J. 196, 149–159.

    Google Scholar 

  12. Berge, R.K., Hosøy, L., and Farstad, M. (1984) Int. J. Biochem., in press.

  13. Nilsson, A., Thomassen, M.S., and Christiansen, E.N. (1984) Lipids 19, 187–194.

    Article  PubMed  CAS  Google Scholar 

  14. Thomassen, M.S., Strøm, E., Christiansen, E.N., and Norum, K.R. (1979) Lipids 14, 58–65.

    Article  PubMed  CAS  Google Scholar 

  15. Flatmark, T., Christiansen, E.N., and Kryvi, H. (1981) Eur. J. Cell. Biol. 24, 62–69.

    PubMed  CAS  Google Scholar 

  16. Lowry, O.H., Rosebrough, N.J., Farr, A.L., and Randall, R.J. (1951) J. Biol. Chem. 193, 265–275.

    PubMed  CAS  Google Scholar 

  17. Dunnett, C.W. (1955) Am. Statistical Ass. J. 50, 1096–1121.

    Article  Google Scholar 

  18. Lalwani, N.D., Reddy, M.K., Mark, M.M., and Reddy, I.K. (1981) Biochem. J. 198, 177–186.

    PubMed  CAS  Google Scholar 

  19. Reddy, I.K., and Kumar, N.S. (1977) Biochem. Biophys. Res. Commun. 77, 824–829.

    Article  PubMed  CAS  Google Scholar 

  20. Numa, S. (1981) Trends Biochem. Sci. 6, 113–115.

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Laboratory of Clinical Biochemistry, University of Bergen, 5016, haukeland Sykeus, Norway

    Rolf K. Berge & Magny S. Thomassen

  2. Institute for Nutrition Research, University of Oslo, Blindern, Oslo 3, Norway

    Rolf K. Berge & Magny S. Thomassen

Authors
  1. Rolf K. Berge
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  2. Magny S. Thomassen
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Berge, R.K., Thomassen, M.S. Effects of high fat diets on the activity of palmitoyl-CoA hydrolase in rat liver. Lipids 20, 49–52 (1985). https://doi.org/10.1007/BF02534363

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  • DOI: https://doi.org/10.1007/BF02534363

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