Abstract
The influence of changes in electrical conductivity, due to the muscle boundary, layers and compartments of intramuscular connective tissue and blood vessels, on computed single-muscle fibre action potentials (SFAPs) in rat hindleg muscle is calculated. The position of the active fibre is varied throughout the muscle. For fibres close to the muscle boundary, peak-to-peak voltages of SFAPs increase by up to a factor of 3 compared with the unbounded situation. For inner fibres, the presence of nearby connective tissue compartments causes an increase of up to 40%. A blood vessel in the neighbourhood of the active fibre leads to a decrease of at most 20%, for recording sites between the active fibre and the blood vessel. For recording sites beyond the blood vessel, peak-to-peak voltages increase by up to 20%.
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Albers, B.A., Rutten, W.L.C., Wallinga, W., andBoom, H.B.K. (1986): ‘A model study on the influence of structure and membrane capacitance on volume conduction in skeletal muscle tissue,’IEEE Trans.,BME-33, pp. 681–689
Albers, B.A., Rutten, W.L.C., Wallinga, W. andBoom, H.B.K. (1988a): ‘Microscopic and macroscopic volume conduction in skeletal muscle tissue, applied to simulation of single fibre action potentials,’Med. Biol. Eng. Comput.,26, pp. 605–610
Albers, B.A., Rutten, W.L.C., Wallinga, W. andBoom, H.B.K. (1988b): ‘Sensitivity of the amplitude of the single muscle fibre action potential to microscopic volume conduction parameters,’ibid.,,26, pp. 611–616
Albers, B.A., Put, J.H.M., Wallinga, W., andWirtz, P. (1989): ‘Quantitative analysis of single muscle fibre action potentials recorded at known distances,’Electroenceph. Clin. Neurophysiol.,73, pp. 245–253.
Barr, R.C., Pilkington, T.C., Boineau, J.P., andSpach, M.S. (1966): ‘Determining surface potentials from current dipoles, with application to electrocardiography,’IEEE Trans.,BME-13, pp. 88–92
Caldwell, J. (1982): ‘Computational methods for solving the Dirichlet problem via Fredholm integral equations,’J. Appl. Phys.,53, pp. 4567–4570
Fleisher, S.M. (1984): ‘Comparative analysis of modelled extracellular potentials,’Med. Biol. Eng. Comput.,22, pp. 440–447
Fleisher, S.M., Studer, M., andMoschytz G.S. (1984): ‘Mathematical model of the single-fibre action potential,’ibid.,22, pp. 433–439
Geddes, L.A., andBaker, L.E. (1967): ‘The specific resistance of biological material—A compendium of data for the biomedical engineer and physiologist,’Med. Biol. Eng.,5, pp. 271–293
Gielen, F.L.H., Cruts, H.E.P., Albers, B.A., Boon, K.L., Wallinga-De Jonge, W., andBoom, H.B.K. (1986): ‘Model of electrical conductivity of skeletal muscle based on tissue structure,’Med. Biol. Eng. Comput.,24, pp. 34–40
Nandedkar, S.D., andTalberg, E. (1983): ‘Simulation of single muscle fiber action potentials,’ibid.,,21, pp. 158–165
Rosenfalck, P. (1969): ‘Intra-and extracellular potential fields of active nerve and muscle fibres. A physicomathematical analysis of different models,’ (Akademisk Forlag, Copenhagen)
Rutten, W.L.C., andAlbers, B.A. (1990): ‘Finite difference modelling of inhomogeneous and frequency-dependent volume conduction in biological tissue’in Grandori, F.,et al., (Eds.): Auditory evoked magnetic fields and electric potentials’ (Karger, Basel), pp. 313–330
Stephanova, D., Trayanova, N., Gydikov, A., andKossev, A. (1989): ‘Extracellular potentials of a single nerve fiber in an unbounded volume conductor,’Biol. Cybern.,61, pp. 205–210
Struijk, J.J., Holsheimer, J., van Veen, B.K., andBoom, H.B.K. (1991): ‘Epidural spinal cord stimulation: calculation of field potentials with special reference to dorsal column nerve fibers,’IEEE Trans.,BME-38, pp. 104–110
Trayanova, N., Henriquez, C.S., andPlonsey, R. (1990): ‘Extracellular potentials and currents of a single active fiber in a restricted volume conductors,’Ann. Biomed. Eng.,18, pp. 219–238
van Veen, B.K., Rutten, W.L.C. andWallinga, W. (1990a): ‘The influence of a frequency-dependent medium around a network model, used for the simulation of single fiber action potentials,’Med. Biol. Eng. Comput.,28, pp. 492–497
van Veen, B. K., Rutten, W.L.C. andWallinga, W. (1990b): ‘The influence of the position of the active fiber relative to the muscle boundary in computing single fiber action potentials,’ Proc. 12th Ann. Conf. of IEEE/EMBS, pp. 2234–2235
van Veen, B.K., Rijkhoff, N.J.M., Rutten, W.L.C., Wallinga, W. andBoom, H.B.K. (1992): ‘Potential distribution and single fiber action potentials in a radially bounded muscle model,’Med. Biol. Eng. Comput.,30, pp. 303–310
Van Veen, B.K., Wolters, H., Wallinga, W., Rutten, W.L.C. andBoom, H.B.K. (1993): ‘The bioelectrical source in computing single muscle fiber action potentials,’Biophys. J.,64, pp. 1492–1498
van Veen, B.K., Mast, E., Busschers, R., Verloop, A.J., Wallinga, W., Rutten, W.L.C., Gerrits, P.O., andBoom, H.B.K. (1994): ‘Single fibre action potentials in skeletal muscle related to recording distances,’J. Electromyogr. Kinesiol.,4, pp. 37–46
Veltink, P.H., van Veen, B.K., Struijk, J.J., Holsheimer, J., andBoom, H.B.K. (1989): ‘A modeling study of nerve fascicle stimulation,’IEEE Trans.,BME-36, pp. 683–691
Wallinga, W., Albers, B.A., Put, J.H.M., Rutten, W.L.C., andWirtz, P. (1988): ‘Activity of single muscle fibres recorded at known distances’,i Wallinga, W., Boom, H.B.K., andDe Vries, J. (Eds.): ‘Electrophysiological kinesiology’ (Elsevier Science Publishers B.V., Amsterdam) pp. 221–224
Zhou, H. (1994): ‘Anisotropic volume conduction in biological media’, PhD Thesis, University of Nijmegen, Nijmegen, The Netherlands
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Rutten, W.L.C., van Veen, B.K., Stroeve, S.H. et al. Influence of inhomogeneities in muscle tissue on single-fibre action potentials: a model study. Med. Biol. Eng. Comput. 35, 91–95 (1997). https://doi.org/10.1007/BF02534136
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DOI: https://doi.org/10.1007/BF02534136