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The incorporation of orally administered radiolabeled dihomo γ-linolenic acid (20∶3ω6) into rat tissue lipids and its conversion to arachidonic acid

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Lipids

Abstract

Radioactivity from orally administered radiolabeled dihomo-γ-linolenic acid (20∶3ω6) was recovered from the liver, plasma and brain lipid fractions. After administration the fatty acid was metabolized to arachidonic acid, the 22 carbon chain length fatty acid, and was also β-oxidized. However, 22 hr after administration of [1-14C]20∶3 between one-third and one-half of the recovered radioactivity was still associated with dihomo-γ-linolenic acid in the liver and plasma lipid fractions. Orally administered dihomo-γ-linolenic acid is incorporated into lipid fractions and is, therefore, available in the metabolic pool for PGE1 synthesis.

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Authors and Affiliations

  1. Department of Biochemistry Nuffield Laboratories of Comparative Medicine, Institute of Zoology, Regent's Park, NW1 4RY, London

    A. G. Hassam & M. A. Crawford

Authors
  1. A. G. Hassam
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  2. M. A. Crawford
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Hassam, A.G., Crawford, M.A. The incorporation of orally administered radiolabeled dihomo γ-linolenic acid (20∶3ω6) into rat tissue lipids and its conversion to arachidonic acid. Lipids 13, 801–803 (1978). https://doi.org/10.1007/BF02533479

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  • DOI: https://doi.org/10.1007/BF02533479

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