Abstract
Gelatin films containing unsaturated lipid have been exposed to ultraviolet and visible irradiation. No sign of paramagnetism could be detected in the films, although the gelatin was undergoing cross-linking reactions. The addition of nitroxyl-forming radical scavengers decreased the rate of cross-linking, as did addition of ascorbic acid to the reacting mixture. Nitroxyls could not be detected in the gels, however. The conclusion is drawn that the main reaction in the cross-linking reaction of collagen is a condensation of amino groups and extrinsic or intrinsic carbonyl groups. The extrinsic aldehydes are formed in the autoxidation of unsaturated lipid.
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Sundholm, F., Visapää, A. & Björksten, J. Cross-linking of collagen in the presence of oxidizing lipid. Lipids 13, 755–757 (1978). https://doi.org/10.1007/BF02533472
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DOI: https://doi.org/10.1007/BF02533472