Abstract
The in vitro conversion of14C-labeled leucine, isoleucine, and pyruvate to specific lipids was compared in rat aorta, diaphragm, and fat pad. Total lipid specific radioactivity from all precursors was greatest in aorta. The ratio of label incorporated into polar lipids vs. neutral lipids by aorta was generally several-fold that incorporated by muscle and fat pad. The labeling of sterols in the aorta from14C-leucine and pyruvate was equivalent. It is concluded that leucine may be a substantial precursor to polar lipids and to sterols in rat aorta.
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Stillway, L.W., Weigand, D.A., Riefler, J.F. et al. Leucine and isoleucine as in vitro precursors for lipid synthesis by rat aorta. Lipids 12, 1012–1016 (1977). https://doi.org/10.1007/BF02533327
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DOI: https://doi.org/10.1007/BF02533327