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Chain length specificity in the utilization of long chain alcohols for ether lipid biosynthesis in rat brain

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Lipids

Abstract

A mixture ofcis-9-[1-14C] octadecenol and [1-14C] docosanol was injected into the brains of 19-day-old rats, and incorporation of radioactivity into brain lipids was determined after 3, 12, and 24 hr. Both alcohols were metabolized by the brain but at different rates; each was oxidized to the corresponding fatty acid, but oleic acid was more radily incorporated into polar lipids. Substantial amounts of radioactivity were incorporated into 18∶1 alkyl and alk-1-enyl moieties of the ethanolamine phosphoglycerides and into 18∶1 alkyl moieties of the choline phosphoglycerides. Even after the disappearance of the 18∶1 alcohol from the substrate mixture (12 hr), the 22∶0 alcohol was not used to any measurable extent for alkyl and alk-1-enyl glycerol formation.

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Authors and Affiliations

  1. The Hormel Institute, University of Minnesota, 55912, Austin, MN

    V. Natarajan & H. H. O. Schmid

Authors
  1. V. Natarajan
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  2. H. H. O. Schmid
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Natarajan, V., Schmid, H.H.O. Chain length specificity in the utilization of long chain alcohols for ether lipid biosynthesis in rat brain. Lipids 12, 872–875 (1977). https://doi.org/10.1007/BF02533279

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  • DOI: https://doi.org/10.1007/BF02533279

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