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Effect of subacute toxic levels of dietary cyclopropenoid fatty acids upon membrane function and fatty acid composition in the rat

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Lipids

Abstract

The effect of subacute toxicity levels of dietary cyclopropenoid fatty acids upon several physiological parameters was determined in the rat. Diets containing 2% corn oil, 2%Sterculia foetida oil or 2% hydrogenatedSterculia foetida oil were fed.Sterculia foetida oil (50% cyclopropenoid fatty acids) fed rats exhibited retarded growth, elevated organ to body wt ratios, increased saturation of tissue lipid, and abnormal histopathology when compared to corn oil and hydrogenatedSterculia foetida oil fed rats. Growth was retarded 50%, liver/body wt doubled, and the percentage of saturated fatty acids in adipose tissue increased 2.5-fold forSterculia foetida oil vs. corn oil comparisons. Three membrane systems were examined in corn oil andSterculia foetida oil fed rats. Erythrocyte hemolysis rate in 0.3 M glycerol was increased by 30%; induction of mitochondrial swelling by reduced glutathione was inhibited completely and microsomal codeine demethylase activity was depressed nearly 50% inSterculia foetida oil fed rats. The ability of cyclopropenoid fatty acids to inhibit fatty acyl desaturase and influence tissue and membrane lipid composition is discussed. Most of the detrimental effects observed in cyclopropenoid fatty acids fed rats may be associated with alteration of normal lipid metabolism and membrane function.

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References

  1. Phelps, R.A., F.S. Shenstone, A.R. Kemmerer, and R.J. Evans, Poult. Sci. 44:358 (1965).

    PubMed  CAS  Google Scholar 

  2. Sinnhuber, R.O., D.J. Lee, J.H. Wales, and J.L. Ayres, J. Nat. Cancer Inst. 41:1293 (1968).

    PubMed  CAS  Google Scholar 

  3. Lee, D.J., J.H. Wales, and R.O. Sinnhuber, Cancer Res. 28:2312 (1968).

    PubMed  CAS  Google Scholar 

  4. Lee, D.J., J.H. Wales, and R.O. Sinnhuber, Ibid. 31:960 (1971).

    PubMed  CAS  Google Scholar 

  5. Miller, A.M., E.T. Sheehan, and M.G. Vavich, Proc. Soc. Exp. Biol. Med. 131:61 (1969).

    PubMed  CAS  Google Scholar 

  6. Doberenz, A.R., D.L. Schneider, A.A. Kurnick, Im. G. Vavich, and A.R. Kemmerer, Ibid. 105:359 (1960).

    PubMed  CAS  Google Scholar 

  7. Raju, P.K., and R. Reiser, J. Biol. Chem. 242:379 (1967).

    PubMed  CAS  Google Scholar 

  8. Johnson,A.R., A.C. Fogerty, J.A. Pearson, F.S. Shenstone, and A.M. Bersten, Lipids 4:1 (1969).

    Article  Google Scholar 

  9. Pande, S.V., and J.F. Meade, J. Biol. Chem. 245:1856 (1970).

    PubMed  CAS  Google Scholar 

  10. Kogle, F., J. De Gier, I. Mulder, and L.M. Van Deenen, Biochim. Biophys. Acta 43:95 (1960).

    Article  Google Scholar 

  11. Walker, B.L., and F.A. Kummerow, Proc. Soc. Exp. Biol. Med. 115:1099 (1964).

    PubMed  CAS  Google Scholar 

  12. March, B.E., V. Coates, and J. Biely, Can. J. Physiol. Pharm. 44:379 (1966).

    CAS  Google Scholar 

  13. Hunter, F.E., Jr., A. Scott, P.E. Hoffsten, J.M. Gebicki, J. Weinstein, and A. Schneider, J. Biol. Chem. 239:614 (1964).

    PubMed  CAS  Google Scholar 

  14. Cochin, J., and J. Axelrod, J. Pharm. Exp. Therap. 125:105 (1959).

    CAS  Google Scholar 

  15. Nash, T., Biochem. J. 55:416 (1953).

    PubMed  CAS  Google Scholar 

  16. Gornall, A.G., C.J. Bardawill, and M.M. David, J. Biol. Chem. 177:751 (1949).

    Google Scholar 

  17. Folch, J., M. Lees, and G.H. Sloane Stanley, Ibid. 226:497 (1957).

    PubMed  CAS  Google Scholar 

  18. Bligh, E.G., and W.J. Dyer, Can. J. Biochem. Physiol. 37:911 (1959).

    PubMed  CAS  Google Scholar 

  19. Hammonds, T.W., J.A. Cornelius, and L. Tan, Analyst 96:659 (1971).

    Article  CAS  Google Scholar 

  20. Pawlowski, N.E., J.E. Nixon, and R.O. Sinnhuber, JAOCS 49:387 (1972).

    PubMed  CAS  Google Scholar 

  21. Schneider, E.L., S.P. Loke, and D.T. Hopkinds, Ibid. 45:585 (1968).

    CAS  Google Scholar 

  22. Ward, T.L., J.S. Tango, E.R. Cousins and R.O. Feuge. Ibid. 44:420 (1967).

    CAS  Google Scholar 

  23. Feron, V.J., A.P. De Groot, M.T. Spanjers, and H.P. Til, Fd. Cosmet. Toxicol. 11:85 (1973).

    CAS  Google Scholar 

  24. Roehm, J.N., D.J. Lee, J.H. Wales, S.D. Polityka, and R.O. Sinnhuber, Lipids 5:80 (1970).

    Article  PubMed  CAS  Google Scholar 

  25. Kircher, H.W., JAOCS 41:4 (1964).

    CAS  Google Scholar 

  26. Ernster, L., P. Siekevitz, and G.E. Palade, J. Cell. Biol. 15:541 (1962).

    Article  CAS  Google Scholar 

  27. Siekevitz, P., “The Molecular Control of Cellular Activity,” Edited by J.M. Allen, McGraw-Hill, New York, N.Y., 1962, p. 143.

    Google Scholar 

  28. Stein, W.D., “The Movement of Molecules Across Cell Membranes,” Academic Press, New York, N.Y., 1967, pp. 65–124.

    Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Food Science and Technology, Oregon State University, 97331, Corvallis, Oregon

    J. E. Nixon, T. A. Eisele, J. H. Wales & R. O. Sinnhuber

Authors
  1. J. E. Nixon
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  2. T. A. Eisele
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  3. J. H. Wales
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  4. R. O. Sinnhuber
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Additional information

Technical paper 3638, Oregon Argricultural Experiment Station, Oregon State University, Corvallis, Oregon 97331.

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Nixon, J.E., Eisele, T.A., Wales, J.H. et al. Effect of subacute toxic levels of dietary cyclopropenoid fatty acids upon membrane function and fatty acid composition in the rat. Lipids 9, 314–321 (1974). https://doi.org/10.1007/BF02533107

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  • DOI: https://doi.org/10.1007/BF02533107

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