Skip to main content
SpringerLink
Log in

Electron spin resonance study of serum lipoproteins of salmon (Oncorhynchus kisutch): Structural alterations produced in high density lipoproteins by mercury and cadmium

  • Published:
Lipids

Abstract

High denisty lipoproteins from the serum of salmon (Oncorhynchus kisutch), containing a maleimide spin label (4-male-imido-2,2,6,6-tetramethylpiperidinooxyl), were exposed to HgCl2, CdCl2, and CH3HgCl under physiological conditions. Electron spin resonance spectrometry revealed that HgCl2 and CdCl2 produce significant alterations at sites representing weakly and strongly immobilized label. The observed changes appear to be taking place primarily in the surface architecture. No alterations were found in the normal spectra of high density lipoproteins exposed to CH3HgCl under similar conditions. Each metal species binds strongly with the apo-high density lipoproteins; however, marked differences exist in the effects produced upon high density lipoprotein structure by the inorganic ions and CH3HgCl.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Reichert, W.L., and D.C. Malins, Nature 247:569 (1974).

    Article  PubMed  CAS  Google Scholar 

  2. Ehrstrom, M., L.E.C. Eriksson, J. Israchlachvili, and A. Ehrenberg, Biochem. Biophys. Res. Comm. 55:396 (1973).

    Article  PubMed  CAS  Google Scholar 

  3. Freeman, N.K., F.T. Lindgren, and A.V. Nichols, in “Progress in the Chemistry of Fats and Other Lipids,” Edited by R.T. Holman, W.O. Lundberg, and T. Malkin, Pergamon Press, New York, N.Y., 1963, p. 218.

    Google Scholar 

  4. Gotto, A.M., and H. Kon, Biochem. Biophys. Res. Comm. 37:444 (1969).

    Article  PubMed  CAS  Google Scholar 

  5. Lowry, O.H., N.J. Rosebrough, A.L. Farr, and R.J. Randall, J. Biol. Chem. 193:265 (1951).

    PubMed  CAS  Google Scholar 

  6. Hanson, S.W.F., and J. Olley, Biochem. J. 89:101 (1963).

    Google Scholar 

  7. Gotto, A.M., H. Kon, and M.E. Birmbaumer, Proc. Natl. Acad. Sci. 65:145 (1970).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Pioneer Research Unit, Northwest Fisheries Center, NMFS, NOAA, 98112, Seattle, Washington

    William L. Reichert & Donald C. Malins

Authors
  1. William L. Reichert
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Donald C. Malins
    View author publications

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

Reichert, W.L., Malins, D.C. Electron spin resonance study of serum lipoproteins of salmon (Oncorhynchus kisutch): Structural alterations produced in high density lipoproteins by mercury and cadmium. Lipids 10, 253–255 (1975). https://doi.org/10.1007/BF02532489

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02532489

Keywords

Search

Navigation