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Effects of ethanol on membrane lipids III. Quantitative changes in lipid and fatty acid composition of nonpolar and polar lipids of mouse total liver, mitochondria and microsomes following ethanol feeding

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Lipids

Abstract

The effects of ethanol on the total, nonpolar, and polar lipids of whole liver, mitochondria, and microsomes have been evaluated. Differences in the fatty acid composition of various lipid subclasses have been compared in control and ethanol treated mice. On the whole polyunsaturated fatty acids, especially arachidonic (20∶4) and docosahexaenoic (22∶6), were found to decrease. The significance of an enzymatic mechanism vs. a peroxidative mechanism to explain the results is discussed. Decreases also were observed in the ratios of arachidonate/linoleate following ethanol feeding. These changes are thought to be associated with decreases in the activity of the chain elongation-desaturation system.

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References

  1. Kiessling, K.H., and L. Pilstrom, Acta Pharm. Tox. Kbh. 24:103 (1966).

    CAS  Google Scholar 

  2. DePury, G.G., and F.D. Collins, Chem. Phys. Lipids 1:1 (1966).

    Article  CAS  Google Scholar 

  3. Hyashida, T., and O.W. Portman, J. Nutr. 81:103 (1963).

    Google Scholar 

  4. Holmer, G., and B. Tronier, Lipids 7:534 (1972).

    Article  PubMed  CAS  Google Scholar 

  5. Klastskin, G., H.M. Gewin, and W.A. Krehl, Yale J. Biol. Med. 23:317 (1951).

    Google Scholar 

  6. Mallov, S., Proc. Soc. Exptl. Biol. Med. 88:246 (1955).

    CAS  Google Scholar 

  7. Fallon, H.S., P.M. Gertman, and E.L. Kemp, Biochem. Biophys. Acta 187:94 (1969).

    PubMed  CAS  Google Scholar 

  8. French, S.W., T.J. Ihrig, and R.J. Morin, Quart. J. Stud. Alc. 31:801 (1970).

    CAS  Google Scholar 

  9. Fallon, H.S., L.A. Persch, and G. Klatskin, Biochem. Biophys. Acta 98:470 (1965).

    PubMed  CAS  Google Scholar 

  10. Lieber, C.S., D.P. Jones, and L.M. DeCarli, J. Clin. Invest. 44:1009 (1965).

    Article  PubMed  CAS  Google Scholar 

  11. Comporti, M., E. Burdino, and F. Raja, Life Sci. 10:885 (1971).

    Article  Google Scholar 

  12. DiLuzio, N.R., and A.D. Hartman, in “Biological and Clinical Aspects of Alcohol Metabolism,” Edited by V.M. Sardesai, Charles C Thomas, Springfield, Ill., 1969, p. 133.

    Google Scholar 

  13. Ferrell, W.J., and J.N. Miceli, Comp. Biochem. Physiol. 41B:19 (1972).

    Google Scholar 

  14. Kiessling, K.H., and C.G. Lundquist, Scand. J. Clin. Lab. Invest. 18(Suppl. 92):80 (1966).

    CAS  Google Scholar 

  15. Ferrell, W.J., and J.N. Miceli, Quart. J. Studies on Alc. 31:810 (1970).

    CAS  Google Scholar 

  16. Hogeboom, G.H., W.C. Schneider, and G.E. Pallade, J. Biol. Chem. 172:619 (1948).

    CAS  Google Scholar 

  17. Barka, T., and P.J. Anderson, “Histochemistry Theory, Practice, and Bibliography,” Harper and Row, New York, N.Y., 1965, p. 120.

    Google Scholar 

  18. Gilbertson, J.R., W.J. Ferrell, and R.A. Gelman, J. Lipid Res. 8:38 (1967).

    PubMed  CAS  Google Scholar 

  19. Miceli, J.N., and W.J. Ferrell, Physiol. Chem. Phys. 4:131 (1972).

    PubMed  CAS  Google Scholar 

  20. Morin, R.J., S. Bernick, J. Mead, and R.B. Alfin-Slater, J. Lipid Res. 3:432 (1962).

    CAS  Google Scholar 

  21. Hashimoto, S., and R.O. Recknagel, Expt. Mol. Pathol. 8:225 (1968).

    Article  CAS  Google Scholar 

  22. Lands, W.E.M., and P. Hart, J. Biol. Chem. 240:1905 (1965).

    PubMed  CAS  Google Scholar 

  23. Mendenhall, C.L., R.H. Bradford, and R.H. Furman, Biochem. Biophys. Acta 187:510 (1969).

    PubMed  CAS  Google Scholar 

  24. French, S.W., and R.J. Morin, in “Biochemical and Clinical Aspects of Alcohol Metabolism,” Edited by V.M. Sardesai, Charles C Thomas, Springfield, Ill., 1969, p. 123.

    Google Scholar 

  25. Reitz, R.C., H. Helsabeck, and D.P. Mason, Lipids 8:80 (1973).

    PubMed  CAS  Google Scholar 

  26. Shaw, G.P., S.W. French, T.J. Ihrig, T.T. Tonaka, and R.J. Morin, Lab. Invest. 24:447 (1971).

    Google Scholar 

  27. Ammon, H.P.T., C.-j. Estler, and F. Heim, Biochem. Pharmacol. 18:29 (1969).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacology, School of Medicine, New York University Medical Center, 10016, New York, New York

    Joseph N. Miceli

  2. Department of Pathology, The University of Michigan, 48104, Ann Arbor, Michigan

    William J. Ferrell

Authors
  1. Joseph N. Miceli
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  2. William J. Ferrell
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Additional information

The research described herein was conducted while the authors were associated with the University of Detroit, Detroit, Mich. and represents part of the work submitted by J.N. Miceli in partial fulfillment of the requirements for the Ph.D. degree.

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Miceli, J.N., Ferrell, W.J. Effects of ethanol on membrane lipids III. Quantitative changes in lipid and fatty acid composition of nonpolar and polar lipids of mouse total liver, mitochondria and microsomes following ethanol feeding. Lipids 8, 722–727 (1973). https://doi.org/10.1007/BF02531839

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  • DOI: https://doi.org/10.1007/BF02531839

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