Abstract
An unsaturated phosphonolipid analogous to phosphatidylethanolamine,rac-dioleoylglyceryl(2-aminoethyl)phosphonate, was synthesized by a general method introduced by Baer for similar saturated substances. An improvement was made in the preparation of the phthalimidoethyl-phosphonic acid precursor.
The phosphonolipid was purified by DEAE cellulose and silicic acid chromatography. It was tested by comparison with synthetic phosphatidyl (dioleoyl) ethanolamine and phosphatidyl(dilinoleoyl) ethanolamine in the Hicks-Pitney test and in a test for prothrombin conversion by using purified blood coagulation factors. In both tests it had more acceleratory activity than the synthetic phosphatidylethanolamines.
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Turner, D.L., Silver, M.J., Holburn, R.R. et al. An unsaturated phosphonic acid analogue of phosphatidylethanolamine and its activity in blood-clotting systems. Lipids 3, 234–238 (1968). https://doi.org/10.1007/BF02531193
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DOI: https://doi.org/10.1007/BF02531193