Abstract
A substrain of the Long Evans rat having the characteristics of a common human lipid disorder, hypertriglyceridemia, is described. These rats were found to be hypercholesterolemic, hyperphospholipidemic and normotriglyceridemic during the first month of life when feeding predominantly on the higher lipid, lower carbohydrate content of their mothers' milk. After weaning (22 days of age), when a typical higher carbohydrate and lower fat containing commercial laboratory feed was substituted for mother's milk, plasma cholesterol and phospholipid levels declined and triglyceride levels significantly increased. Electrophoretic analysis of lipoproteins revealed the presence of a pre-β fraction and the absence of chylomicra, indicating that this rat is a type IV according to the Fredrickson classification system. Glucose tolerance curves remained elevated for a longer period of time and returned to normal more slowly in 1 year old compared to 2 month old males, indicating progressive alterations in glucose metabolism common in a Fredrickson type IV. After weaning, plasma phospholipid, cholesterol and triglyceride levels were significantly higher and body weight significantly lower in the female than in the male. Studies on hematocrit and hemoglobin variations with respect to age in both sexes indicated that the observed plasma lipid changes could not be attributed to hemoconcentration.
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Lenz, P.H., Fleischman, A.I. Variation in plasma lipids with age and sex in a hypertriglyceridemic rat. Lipids 4, 384–387 (1969). https://doi.org/10.1007/BF02531010
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DOI: https://doi.org/10.1007/BF02531010