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Survival benefit of D2 lymphadenectomy in patients with gastric adenocarcinoma

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Abstract

Background

A definite resolution to the controversy on the optimal extension of lymph node dissection (LND) in gastric cancer has not been achieved. Surgical morbidity and survival of D1 and D2 LND are compared by multivariate analysis.

Methods

A retrospective cohort study of 219 patients with gastric cancer and curative resection performed according to Japanese rules. D1 dissection was performed in 106 cases and D2 in 113. The logistic regression model was used to define risk factors for surgical morbidity and the Cox model to determine prognostic factors.

Results

Surgical morbidity occurs in 16.9% and 19.5% in D1 and D2 LND, respectively (P=.7). The morbidity determinants were operation blood loss, splenectomy, pancreaticosplenectomy, antrum location, low serum albumin, total gastrectomy, and metastatic nodal ratio (P<.0001), but not D2 LND. Five-year survival was 35.1% for D1 and 64% for D2 LND (P<.039). The prognostic factors were T stage, N stage, serum albumin level, total gastrectomy, D2 LND, and comorbidity (P<.0001).

Conclusions

The increment of surgical morbidity and mortality rates attributed to D2 LND is largely caused by the effect of splenectomy and pancreaticosplenectomy. A significant survival benefit because of D2 LND was found. The results support the value of extended LND in the surgical treatment of gastric cancer.

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Authors and Affiliations

  1. Departamento de Gastroenterologia, Instituto Nacional de Cancerología, Avenida San Fernando 22, Colonia Toriello Guerra, Tlalpan, 14000, Mexico DF, Mexico

    Luis F. Oñate-Ocaña MD, Vincenzo Aiello-Crocifoglio MD, Ricardo Mondragón-Sánchez MD & Juan M. Ruiz-Molina MD

Authors
  1. Luis F. Oñate-Ocaña MD
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  2. Vincenzo Aiello-Crocifoglio MD
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  3. Ricardo Mondragón-Sánchez MD
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  4. Juan M. Ruiz-Molina MD
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Correspondence to Luis F. Oñate-Ocaña MD.

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Oñate-Ocaña, L.F., Aiello-Crocifoglio, V., Mondragón-Sánchez, R. et al. Survival benefit of D2 lymphadenectomy in patients with gastric adenocarcinoma. Annals of Surgical Oncology 7, 210–217 (2000). https://doi.org/10.1007/BF02523656

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  • DOI: https://doi.org/10.1007/BF02523656

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