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Refined staging by sentinel lymph node biopsy to individualize therapy in anal cancer

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Abstract

We evaluated the feasibility of the sentinel lymph node technique to refine staging and potentially individualize therapy for anal cancer. Seventeen patients with cancer of the anal canal underwent peritumoral injection of99mTc-colloid, followed 17 hours later by lymphoscintigraphy. A selective lymph node biopsy (SLNB) was attempted in 12 of 13 cases with scintigraphically detected SLNs. Lymph node metastases were present in 5 of 12 cases (42%); in 2 of these 5 cases, micrometastases were detected only by immunohistochemical staining. Hence, SLNB refines the diagnostic workup for anal cancer and provides an accurate basis for individualized therapy.

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Authors and Affiliations

  1. Department of Surgery and Surgical Oncology, University Hospital Charité, Campus Buch, Robert Roessle Klinik at the Helios Klinikum, Lindenberger Weg 80, 13125, Berlin, Germany

    Christoph Ulmer MD, Andreas Bembenek MD, Stephan Gretschel MD & Peter Michael Schlag MD, PhD

  2. Division of Nuclear Medicine, University Hospital Charité, Campus Buch, Robert Roessle Klinik at the Helios Klinikum, Lindenberger Weg 80, 13125, Berlin, Germany

    Jörn Markwardt MD

  3. Division of Pathology, University Hospital Charité, Campus Buch, Robert Roessle Klinik at the Helios Klinikum, Lindenberger Weg 80, 13125, Berlin, Germany

    Ulrike Schneider MD

  4. Division of Radiotherapy, University Hospital Charité, Campus Buch, Robert Roessle Klinik at the Helios Klinikum, Lindenberger Weg 80, 13125, Berlin, Germany

    Stephan Koswig MD

Authors
  1. Christoph Ulmer MD
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  2. Andreas Bembenek MD
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  3. Stephan Gretschel MD
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  4. Jörn Markwardt MD
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  5. Stephan Koswig MD
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  6. Ulrike Schneider MD
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  7. Peter Michael Schlag MD, PhD
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Correspondence to Peter Michael Schlag MD, PhD.

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Ulmer, C., Bembenek, A., Gretschel, S. et al. Refined staging by sentinel lymph node biopsy to individualize therapy in anal cancer. Annals of Surgical Oncology 11 (Suppl 3), 259S–262S (2004). https://doi.org/10.1007/BF02523641

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  • DOI: https://doi.org/10.1007/BF02523641

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