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Synthesis of11C propranolol

  • Medical Radionuclides and the Quality of Radiopharmaceuticals
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Abstract

A method is described by which 60 mCi11C propranolol may be obtained from about 1 Ci11CO2 in 30 min without irradiation risk for personnel. The product is chromatographically pure, sterile and apyrogenic with a specific activity between 500 mCi and 2 Ci/μmole at the time of use. The synthesis involves the preparation of11C acetone followed by fixation of the isopropyl group on the precursor [1-amino-3-(1-naphtyloxy)-2-propanol] by formation of an imine, then reduction of the latter by sodium cyanoboro hydride. The influence of certain parameters (reagents, precursor, impurities) on the final product is discussed.

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References

  1. M. E. CONOLLY, F. KERSTING, C. T. DOLLERY, Prog. Cardiovasc. Dis., 19 (1976) 203.

    Article  CAS  Google Scholar 

  2. C. T. DOLLERY, A. F. JUNOD, Br. J. Pharmacol., 57 (1976) 67.

    CAS  Google Scholar 

  3. P. J. BARNES, J. S. KARLINER, C. T. DOLLERY, Clin. Sci., 58 (1980) 457.

    CAS  Google Scholar 

  4. R. B. WALKER, W. L. NELSON, Label. Comp. Radiopharm., 14 (1977) 905.

    Article  Google Scholar 

  5. A. ARFWIDSSON, G. HALLHAGEN, K. J. HOFFMANN, J. Label. Comp. Radiopharm., 17 (1979) 369.

    Article  Google Scholar 

  6. O. BUCHMAN, I. PRI-BAR, Y. HAGAG, J. Label. Comp. Radiopharm., 10 (1974) 519.

    Article  CAS  Google Scholar 

  7. R. R. MUCCINO, L. SERICO, J. Label. Comp. Radiopharm., 15 (1978) 529.

    Article  CAS  Google Scholar 

  8. J. BURNS, J. Label. Comp. Radiopharm., 6 (1970) 45.

    Article  CAS  Google Scholar 

  9. O. M. BAKKE, D. S. DAVIES, L. DAVIES, C. T. DOLLERY, Life Sci., 13 (1973) 1665.

    Article  CAS  Google Scholar 

  10. S. TEGNER, Acta Chem. Scand., 6 (1952) 782.

    Article  CAS  Google Scholar 

  11. H. GILMAN, P. R. VAN ESS, J. Am. Chem. Soc., 55 (1933) 1258.

    Article  CAS  Google Scholar 

  12. G. BERGER, M. MAZIERE, C. PRENANT, D. COMAR, Intern. J. Appl. Radiat. Isot., 31 (1980) 577.

    Article  CAS  Google Scholar 

  13. R. F. BORCH, M. D. BERNSTEIN, H. DUPONT DURST, J. Am. Chem. Soc., 93 (1971) 2897.

    Article  CAS  Google Scholar 

  14. G. BERGER, M. MAZIERE, R. KNIPPER, C. PRENANT, D. COMAR, Intern. J. Appl. Radiat. Isot., 30 (1979) 393.

    Article  CAS  Google Scholar 

  15. M. MAZIERE, J. M. GODOT, G. BERGER, C. PRENANT, D. COMAR, J. Radioanal. Chem., 56 (1980) 229.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Commissariat a l'Energie Atomique Département; de Biologie, Service Hospitalier Frédéric Joliot, 91406, Orsay, (France)

    G. Berger, M. Maziere, C. Prenant, J. Sastre, A. Syrota & D. Comar

Authors
  1. G. Berger
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  2. M. Maziere
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  3. C. Prenant
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  4. J. Sastre
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  5. A. Syrota
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  6. D. Comar
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Berger, G., Maziere, M., Prenant, C. et al. Synthesis of11C propranolol. J. Radioanal. Chem. 74, 301–306 (1982). https://doi.org/10.1007/BF02520381

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  • DOI: https://doi.org/10.1007/BF02520381

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