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A preliminary comparative assessment by activation analysis of some of the materials and containers used in pharmaceutical manufacture

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Abstract

Neutron activation analysis has been used in a preliminary, comparative assessment of some of the materials and containers employed in pharmaceutical manufacture. Microgram and submicrogram amounts of manganese, copper, and sodium have been determined in water distilled and redistilled from stainless steel and pyrex glass stills. The leaching of these elements by distilled and doubly distilled water from stainless steel, pyrex glass, and polyethylene storage containers has also been studied. The Mn, Cu, and Na contents of polyethylene bottles were also determined. The same techniques were used to determined these impurities as well as As, Au, and Sb in adrenaline and vitamin C.

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Author notes

  1. B. S. Poey

    Present address: Institute Teknologi Bandung, 16 Djl. Adipati, Kertabumi, Bandung, (Indonesia)

Authors and Affiliations

  1. Research Reactor Facility, University of Missouri, Columbia, Missouri, (USA)

    B. S. Poey & G. W. Leddicotte

Authors
  1. B. S. Poey
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  2. G. W. Leddicotte
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Poey, B.S., Leddicotte, G.W. A preliminary comparative assessment by activation analysis of some of the materials and containers used in pharmaceutical manufacture. J. Radioanal. Chem. 2, 425–433 (1969). https://doi.org/10.1007/BF02518470

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  • DOI: https://doi.org/10.1007/BF02518470

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