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The effect of prophylaxis for thrombosis on heterotopic ossification following total hip joint replacement

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Summary

The effect of prophylaxis for thrombosis on heterotopic ossification was investigated using 216 total hip joint endoprostheses implanted between 1976 and 1978. During this period a random comparative study of low dose heparin and oxyphenbutazone / acetylsalycilic acid was carried out. The rate of ossification in the 216 hip joints was 17.6%, and was about average for the values specified in literature on this subject. Heterotopic ossification occurred in 30.1% of the 103 hip joints treated with heparin, whilst the rate of ossification in the 113 hip joints treated with oxyphenbutazone / acetylsalycilic acid was only 6.2%. This represents a statistically significant difference in disfavour of prophylaxis with heparin.

Zusammenfassung

Der Einfluß der Thromboseprophylaxe auf periartikuläre Verknöcherungen wurde bei 216 Hüfttotalendoprothesen der Jahre 1976–1978 untersucht. In diesem Zeitraum lief eine randomisierte, vergleichende Studie zwischen low dose-Heparin und Oxyphenbutazon / Acetylsalycilsäure. Die Verknöcherungsrate der 216 Hüftgelenke betrug 17,6% und lag somit im Durchschnitt der in der Literatur angebenen Werte. Bei den 103 mit Heparin behandelten Hüftgelenken traten in 30.1% der Fälle periartikulare Verknöcherungen auf, während die Verkalkungsrate bei den 113 Hüftgelenken mit Oxyphenbutazon / Acetylsalycilsäure-Prophylaxe nur 6,2% betrug. Dies ist ein statistisch signifikanter Unterschied zuungunsten der Heparinprophylaxe.

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  1. Orthopädisches Krankenhaus der Stadt Wien-Gersthof, Allgemeine Orthopädische Abteilung, Wielemansgasse 28, A-1180, Wien, Austria

    R. Eyb & K. Knahr

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  1. R. Eyb
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  2. K. Knahr
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Eyb, R., Knahr, K. The effect of prophylaxis for thrombosis on heterotopic ossification following total hip joint replacement. Arch. Orth. Traum. Surg. 102, 114–117 (1983). https://doi.org/10.1007/BF02498727

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