Abstract
Alkylation of thiophosphorylacetonitriles under phase transfer catalysis conditions in the 50% NaOH/CH2Cl2 system proceeds as monoalkylation, whereas alkylation in MeCN with the use of solid KOH as a base gives a disubstituted product. The order in which the reagents were added as well as dilution of the reaction mixture affected substantially the yields of the target compounds. X-ray diffraction analysis of a single crystal of dibutyl(diphenylthiophosphoryl)acetonitrile was carried out.
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Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 5, pp. 990–996, May, 1998.
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Odinets, I.L., Vinogradova, N.M., Artyushin, O.I. et al. SelectiveC-mono- andC,C-dialkylation of thiophosphorylacetonitriles. Russ Chem Bull 47, 960–966 (1998). https://doi.org/10.1007/BF02498169
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DOI: https://doi.org/10.1007/BF02498169