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Electrical activity in dorsal horns of the spinal cord and in sensorimotor cortex in rats with the spinal pain syndrome

  • General Pathology and Pathological Physiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

In rats with the spinal pain syndrome caused by penicillin application to the dorsal surface of lumbar segments of the spinal cord, the following changes in evoked potentials were observed in the dorsal horn in L5 segment at the side of penicillin application: a marked increase in primary response and disappearance of the secondary hyperpolarization wave with its replaument by a high-amplitude and long depolarizing wave. In addition to these changes, repetitive spontaneous burst discharges were recorded in the corresponding region of the sensorimotor cortex. Thus, the pathogenic basis of the pain syndrome is a pathological algetic system formed of altered structures that belong to nociceptive apparatus in dorsal horn and higher subdivision of the pain sensory system.

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Authors and Affiliations

  1. Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow

    G. N. Kryzhanovskii, V. A. Zinkevich, S. I. Igon'kina, V. V. Chalova, V. K. Reshetnyak & M. L. Kukushkin

Authors
  1. G. N. Kryzhanovskii
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  2. V. A. Zinkevich
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  3. S. I. Igon'kina
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  4. V. V. Chalova
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  5. V. K. Reshetnyak
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  6. M. L. Kukushkin
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 3, pp. 269–272, March, 1998

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Kryzhanovskii, G.N., Zinkevich, V.A., Igon'kina, S.I. et al. Electrical activity in dorsal horns of the spinal cord and in sensorimotor cortex in rats with the spinal pain syndrome. Bull Exp Biol Med 125, 236–238 (1998). https://doi.org/10.1007/BF02496868

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  • DOI: https://doi.org/10.1007/BF02496868

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