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Study of mouse synaptonemal complex after injection of camptotecin

  • Genetics
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Total synaptonemal complexes of male mouse meiotic chromosomes were examined under electron microscope at different periods after a single injection of the antitumor drug camptotecin. At the stage of meiosis prophase I, the drug induced sharp decondensation of chromatin, distention of chromosomes and elements of synaptonemal complex, and blocked desynapsis of homologous chromosomes at the diplotene stage, thus “arresting” damaged cells. The effect of camptotecin lasted 34 days after injection and involved 15 to 90% cells in different periods.

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Authors and Affiliations

  1. Department of Cytogenetics, N. I. Vavilov Institute of General Genetics, Moscow

    T. V. Sukhacheva & O. L. Kolomiets

  2. Institute of Gene Biology, Russian Academy of Sciences, Moscow

    E. F. Loseva

Authors
  1. T. V. Sukhacheva
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  2. O. L. Kolomiets
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  3. E. F. Loseva
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 1, pp. 84–88, January, 1998

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Sukhacheva, T.V., Kolomiets, O.L. & Loseva, E.F. Study of mouse synaptonemal complex after injection of camptotecin. Bull Exp Biol Med 125, 71–75 (1998). https://doi.org/10.1007/BF02496806

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  • DOI: https://doi.org/10.1007/BF02496806

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