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Effect of ±1-acid glycoprotein glycoforms on the production of tumor necrosis factor and interleukin-1 by human peripheral blood mononuclear leukocytesin vitro

  • Microbiology and Immunology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Effects of various glycoforms of ±1-acid glycoprotein on the production of tumor necrosis factor and interleukin-1 are studied. After fractionation of donor blood or ascitic fluid from cancer patients 4 glycoforms were obtained, differing by affine binding to concanavalin A and by the carbon chain structure. Different glycoforms of ±1-acid glycoprotein inhibit or stimulate the production of tumor necrosis factor-α and interleukin-1β by peripheral blood mononuclears. The glycoform with the highest affinity for ConA produced the strongest stimulating effect.

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Authors and Affiliations

  1. Medico-Genetic Research Center, Russian Academy of Medical Sciences, Moscow

    A. L. Pukhal'skii, E. A. Kalashnikova, S. D. Shiyan & N. V. Bovin

  2. M. M. Shemyakin Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow

    A. L. Pukhal'skii, E. A. Kalashnikova, S. D. Shiyan & N. V. Bovin

Authors
  1. A. L. Pukhal'skii
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  2. E. A. Kalashnikova
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  3. S. D. Shiyan
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  4. N. V. Bovin
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 1, pp. 79–83, January, 1998

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Pukhal'skii, A.L., Kalashnikova, E.A., Shiyan, S.D. et al. Effect of ±1-acid glycoprotein glycoforms on the production of tumor necrosis factor and interleukin-1 by human peripheral blood mononuclear leukocytesin vitro . Bull Exp Biol Med 125, 67–70 (1998). https://doi.org/10.1007/BF02496805

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  • DOI: https://doi.org/10.1007/BF02496805

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