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Balysum-2 inhibitis evoked activity of the pyramidal neurons in hippocampus

  • Pharmacology and Toxicology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The effects of Balysum-2 on the responsiveness of field CA1 hippocampal pyramidal neurons was studied in experiments with cultured cerebral slices. Addition to the medium of 10−4M Balysum-2 or its active ingredient (comenic acid) led to a reversible decrease in the peak amplitude of focal response (pop-spike) recorded in the pyramidal layer CA1 during stimulation of the radial layer. Perfusion of hippocampal slices with a solution containing the noncompetitive GABAA-antagonist picrotoxin prevented the effects of Balysum-2 and comenic acid. Inhibition of hippocampal pyramids by Balysum-2 and comenic acid is probably caused by an incease in the inhibitory effect mediated by GABAA-receptors.

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Authors and Affiliations

  1. Department of Biologicaly Active Compounds, Kuban State University, Krasnodar

    A. A. Khrapov, A. N. Chepkova, A. Ya. Shurygin & V. G. Skrebitskii

  2. Laboratory of Functional Sinaptology, Institute of Brain Research, Russian Academy of Medical Sciences, Moscow

    A. A. Khrapov, A. N. Chepkova, A. Ya. Shurygin & V. G. Skrebitskii

Authors
  1. A. A. Khrapov
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  2. A. N. Chepkova
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  3. A. Ya. Shurygin
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  4. V. G. Skrebitskii
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Translated fromByulleten' Eksperimental'noi Biologii I Meditsiny, Vol. 125, No. 1, pp. 63–65, January, 1998

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Khrapov, A.A., Chepkova, A.N., Shurygin, A.Y. et al. Balysum-2 inhibitis evoked activity of the pyramidal neurons in hippocampus. Bull Exp Biol Med 125, 53–55 (1998). https://doi.org/10.1007/BF02496801

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  • DOI: https://doi.org/10.1007/BF02496801

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