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Novel syntheses of symmetrical 2,5-diaryl-1,3,4-oxadiazoles and 1,4-phenylenebis-1,3,4-oxadiazoles

  • Organic Chemistry
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Russian Chemical Bulletin Aims and scope

Abstract

The reactions of trichloromethylarenes with excess hydrazine hydrate in ethanol gives symmetrical 2,5-diaryl-1,3,4-oxadiazoles in 68–96% yields. The reaction of 1,4-bis(trichloromethyl)benzene with acylhydrazines in an ethanol-pyridine mixture gives the corresponding substituted or unsubstituted 1,4-phenylenebis-1,3,4-oxadiazoles in 35–51% yields. The mass spectra of 2,5-diaryl-1,3,4-oxadiazoles and 1,4-phenylenebis-1,3,4-oxadiazoles were studied.

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Authors and Affiliations

  1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 117913, Moscow, Russian Federation

    L. I. Belen'kii, S. I. Luiksaar, I. S. Poddubnyi & M. M. Krayushkin

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  1. L. I. Belen'kii
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  2. S. I. Luiksaar
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  3. I. S. Poddubnyi
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  4. M. M. Krayushkin
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Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2309–2316, November, 1998.

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Belen'kii, L.I., Luiksaar, S.I., Poddubnyi, I.S. et al. Novel syntheses of symmetrical 2,5-diaryl-1,3,4-oxadiazoles and 1,4-phenylenebis-1,3,4-oxadiazoles. Russ Chem Bull 47, 2238–2245 (1998). https://doi.org/10.1007/BF02494289

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  • DOI: https://doi.org/10.1007/BF02494289

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