Summary
This paper describes a TLC-densitometric procedure for identification and determination of bisoprolol, labetalol, and propafenone in pharmaceutical preparations. The compounds were derivatized with dabsyl chloride and chromatographed on silica gel by ascending development. The separation of the dabsylated drugs was followed by densitometric quantitation. The method was satisfactorily applied to pharmaceutical preparations. TheRSD of quantitation was between 1.6 and 2.3%.
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Witek, A., Hopkala, H. & Matysik, G. TLC-densitometric determination of bisoprolol, labetalol and propafenone, as dabsyl derivatives, in pharmaceutical preparations. Chromatographia 50, 41–44 (1999). https://doi.org/10.1007/BF02493615
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DOI: https://doi.org/10.1007/BF02493615