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Liver transplantation for metastatic gut autonomic nerve (GAN) tumor: Case report and review of the literature

  • Case Reports of Interest
  • Published:
Journal of Hepato-Biliary-Pancreatic Surgery

Abstract

A 24-year-old woman underwent gastrectomy because of a gut autonomic nerve (GAN) tumor originating from the gastric antrum; three synchronous liver metastases were also resected. Liver resection was repeated twice, due to recurring liver metastases. After a disease-free period of 2 years, liver transplantation was felt to be indicated because of the presence of non-resectable, recrudescent liver metastases. Nearly 5 years after orthotopic liver transplantation, there are no signs of clinical or biological tumor recurrence. In view of the literature, liver transplantation may very well be indicated in the presence of liver metastases stemming from GAN tumors which originate from the proximal gastrointestine.

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References

  1. Cordell JL, Falim B, Erber WN (1984) Immunoenzymatic labeling of monoclonal antibodies using immune complex of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes). J Histochem Cytochem 32:219–229

    PubMed  CAS  Google Scholar 

  2. Herrara GA, De Morares HP, Grizzle WE, Hau GE (1984) Malignant small bowel neoplasm of enteric plexus derivation (plexosarcoma). Light and electronmicroscopic study confirming the origin of the neoplasm. Dig Dis Sci 29:275–284

    Article  Google Scholar 

  3. Herrara GA, Cerezo L, Jones JE, Sack J, Grizzle WE, Pollack WJ, Lott RL (1989) Gastrointestinal autonomic nerve tumors “plexosarcomas”. Arch Pathol Lab Med 113:846–853

    Google Scholar 

  4. Walker P, Dvorak AM (1986) Gastrointestinal autonomic nerve (GAN) tumor. Ultrastructural evidence of a newly recognized entity. Arch Pathol Lab Med 110:306–316

    Google Scholar 

  5. Scheithauer BW, Nora FE, Lechago J, Wick MR, Crawford BG, Weiland LH, Carney JA (1986) Duodenal gangliocytic paraganglioma. Am J Clin Pathol 86:559–565

    PubMed  CAS  Google Scholar 

  6. Böhm J, Radebold K, Meister P, Höfler H (1991) Tumor des autonomen Nervensystems des Magens (GAN-Tumor): Fallbericht einer seltenen und neuen Entität. Verh Dtsch Ges Pathol 75:283

    Google Scholar 

  7. Lauwers GY, Erlandson RA, Casper ES, Murray FB, Woodruff JM (1993) Gastrointestinal autonomic nerve tumors: A clinicopathological, immunohistochemical and ultrastructural study of 12 cases. Am J Surg Pathol 17:887–897

    Article  PubMed  CAS  Google Scholar 

  8. Segal A, Carello S, Caterina P, Papadimitriou JM, Spagnolo DV (1994) Gastrointestinal autonomic nerve tumors: A clinicopathological, immunohistochemical and ultrstructural study of ten cases. Pathology 26:439–447

    Article  PubMed  CAS  Google Scholar 

  9. Thomas JR, Mrak RE, Libuit N (1994) Gastrointestinal autonomic nerve tumor presenting as a high grade sarcoma: Case report and review of literature. Dig Dis Sci 39:2051–2055

    Article  PubMed  CAS  Google Scholar 

  10. Kodet R, Snadjauf J, Smelhaus V (1994) Gastrointestinal autonomic nerve tumor: A case report with electron microscopic and immunohistochemical analysis and review of the literature. Pediatr Pathol 14:1005–1006

    PubMed  CAS  Google Scholar 

  11. Pichlmayr R, Weimann A, Ringe B (1994) Indications for liver transplantation in hepatobiliary malignancy. Hepatology 20:33–40

    Article  Google Scholar 

  12. Frilling A, Rogiers X, Knöfel WT, Broelsch CE (1994) Liver transplantation for metastatic carcinoid tumors. Digest 55:104–106

    Article  Google Scholar 

  13. Anthuber M, Jauch KW, Briegel J, Groh J, Schildberg FW (1996) Results of liver transplantation for gastroenteropancreatic tumor metastases. World J Surg 20:73–76

    Article  PubMed  CAS  Google Scholar 

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Harms, J., Heidecke, C.D., Boehm, J. et al. Liver transplantation for metastatic gut autonomic nerve (GAN) tumor: Case report and review of the literature. J Hep Bil Pancr Surg 4, 346–350 (1997). https://doi.org/10.1007/BF02489036

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  • DOI: https://doi.org/10.1007/BF02489036

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