Skip to main content

Effects of sevoflurane and halothane anesthesia on liver circulation and oxygen metabolism in the dog during hepatolobectomy



Effects of sevoflurane and halothane anesthesia on liver circulation and oxygen metabolism during hepatolobectomy were investigated in the dog, with the aim of choosing a better anesthetic for hepatic resection.


Sixteen mongrel dogs were randomly divided into two groups with eight in each. Electromagnetic flowmeters were used to measure hepatic arterial and portal venous blood flows (1) before the inhalation of each anesthetic (base line); (2) 1 h after the start of inhalation of 1.5 minimum alveolar concentration (MAC) anesthetic; (3) 1 h after hepatolobectomy with the same MAC of anesthesia; and (4) 2 h after the discontinuation of anesthesia. Measurements of systemic hemodynamics, blood gas tensions, plasma enzyme leaks and arterial ketone body ratio were made at the same time.


Sevoflurane maintained hepatic arterial blood flow better than halothane anesthesia, both before and after hepatolobectomy. Hepatic arterial vascular resistance increased in the halothane group but did not change in the sevoflurane group after hepatolobectomy. No significant difference was found in oxygen metabolism and arterial ketone body ratio between two groups. Serum enzyme leakage was less in the sevoflurane group.


Sevoflurane has less adverse effects on liver circulation, especially hepatic arterial blood flow, and hepatic function than halothane in the case of hepatolobectomy.

This is a preview of subscription content, access via your institution.


  1. Andreen M, Irestedt L, Zetterstrom B (1977) The different responses of the hepatic arterial bed to hypovolaemia and to halothane anesthesia. Acta Anaesth Scand 21:457–469

    PubMed  CAS  Article  Google Scholar 

  2. Hughes RL, Campbell D, Fitch W (1980) Effects of enflurane and halothane on liver blood flow and oxygen consumption in the greyhound. Br J Anaesth 52:1079–1086

    PubMed  CAS  Google Scholar 

  3. Gelman S, Fowler KC, Smith LR (1984) Liver circulation and function during isoflurane and halothane anesthesia. Anesthesiology 61:726–730

    PubMed  CAS  Google Scholar 

  4. Gelman S (1987) General anesthesia and hepatic circulation. Can J Physiol 65:1762–1779

    CAS  Google Scholar 

  5. Frink EJ, Brown BRJ (1993) Sevoflurane. Bailliere's Clin Anesthesiol 7:899–913

    Article  Google Scholar 

  6. Andreen M (1982) Inhalation versus intravenous anesthesia. Effects on the hepatic and splanchnic circulation. Acta Anaesthesiol Scand 75 (suppl):25–31

    CAS  Article  Google Scholar 

  7. Thomson IA, Fitch W, Hughes RL, Campbell D (1983) Effect of increased concentration of carbon dioxide during halothane anesthesia on liver blood flow and hepatic oxygen consumption. Br J Anaesth 55:1231–1237

    PubMed  CAS  Google Scholar 

  8. Merin RG, Bernard JM, Doursout MF, Cohen M, Chelly JE (1991) Comparison of the effects of isoflurane and desflurane on cardiovascular dynamics and regional blood flow in chronically instrumented dogs. Anesthesiology 74:568–574

    PubMed  CAS  Google Scholar 

  9. Frink EJ, Morgan SE, Coetzee A, Conzen PF, Brown BR (1992) The effects of sevoflurane, halothane, enflurane, and isoflurane on hepatic blood flow and oxygenation in chronically instrumented greyhound dogs. Anesthesiology 76:85–90

    PubMed  CAS  Google Scholar 

  10. Bernard JM, Doursout MF, Wounters P, Hartley CJ, Merin RG, Chelly JE (1992) Effects of sevoflurane and isoflurane on hepatic circulation in the chronically instrumented dogs. Anesthesiology 77:541–545

    PubMed  CAS  Google Scholar 

  11. Richardson PDI, Withrington P (1975) Liver blood flow. I. Intrinsic and nervous control of liver blood flow. Gastroenterology 81:159–173

    Google Scholar 

  12. De Jong RH, Eger EI II (1975) MAC expanded: AD50 and AD95 values of common inhalation anesthetics in man. Anesthesiology 42:384–389

    PubMed  Google Scholar 

  13. Thomson IA, Fitch W, Hughes RL, Campbell D, Watson R (1986) Effects of certain i.v. anaesthetics on liver blood flow and hepatic oxygen consumption in the greyhound. Br J Anaesth 58:69–80

    PubMed  CAS  Google Scholar 

  14. Lautt WW (1985) Mechanism and role of intrinsic regulation of hepatic arterial blood flow: hepatic arterial buffer response. Am J Physiol 249:G549-G556

    PubMed  CAS  Google Scholar 

  15. Sigmon DH, Florentino-Pineda I, Van Dyke RA, Beierwaltes WH (1995) Halothane impairs the hemodynamic influence of endothelium-derived nitric oxide. Anesthesiology 82:135–143

    PubMed  CAS  Article  Google Scholar 

  16. Gelman S, Van Dyke RA (1988) Mechanism of halothane-induced hepatotoxicity: another step on a long path. Anesthesiology 68:479–482

    PubMed  CAS  Google Scholar 

  17. Gelman S (1976) Disturbances in heaptic blood flow during anesthesia and surgery. Arch Surg 111:881–883

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


About this article

Cite this article

Yu, Bw., Matsumoto, N. Effects of sevoflurane and halothane anesthesia on liver circulation and oxygen metabolism in the dog during hepatolobectomy. J Anesth 11, 213–218 (1997).

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI:

Key words

  • Inhalation anesthetic
  • Sevoflurane
  • Halothane
  • Hepatic circulation
  • Hepatolobectomy