Abstract
Hydrolyzable polyrotaxanes, in which many α-cyclodextrins (α-CD) are threaded onto a poly(ethylene glycol) (PEG) chain capped withl-phenylalanine via ester linkages, were synthesized to estimate the supramolecular dissociation via terminal ester hydrolysis. The polyrotaxane showed unique thermoresistant properties due to the supramolecular structure. The supramolecular structure was completely dissociated by terminal ester hydrolysis. PEG hydrogels cross-linked with the polyrotaxane were prepared as new candidate implantable materials for tissue engineering. It is suggested that controlling the rate of terminal ester hydrolysis and the following supramolecular dissociation may dominate the disappearance of the hydrogel. These findings will be of great importance for designing a scaffold based on the primary structure of the polyrotaxane that shows dual characteristics of excellent mechanical properties and perfect disappearance from an implanted site.
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Watanabe, J., Ooya, T. & Yui, N. Feasibility study of hydrolyzable polyrotaxanes aiming at implantable materials. J Artif Organs 3, 136–142 (2000). https://doi.org/10.1007/BF02479980
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DOI: https://doi.org/10.1007/BF02479980