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A voltage clamp circuit for measuring rapid current transients in membranes

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Abstract

A voltage clamp circuit is described which permits the measurements of current transients in membranes with time constants of the order of microseconds. The resistance Rs in series with the membrane is compensated for by a current feedback circuit which produces a rapid charging of the membrane capacitance C. It is possible by this arrangement to reduce the charging period to a value considerably shorter than the time constant RsC.

Sommaire

L'article décrit un circuit de blocage de la tension qui permet de mesurer les courants transitoires dans les membranes avec une constante de durée de l'ordre des microsecondes. La résistance (R s) en série avec la membrane est compensée par un circuit à courant rétroactif qui produit un chargement rapide de la capacitance (C) de la membrane. Il est possible grâce à ce système de réduire la période de charge jusqu'à une valeur considérablement plus courte que la constante de durée (R sC).

Zusammenfassung

Es wird eine Spannungsklemmschaltung beschrieben, durch die Messungen des Übergangsstroms in Membranen mit Zeitkonstanten in der Größenordnung von Mikrosekunden möglich sind. Der mit der Membrane in Serie geschaltete Widerstand (R s) wird durch eine Stromrückkoppelungsschaltung ausgeglichen, die eine schnelle Ladung der Membrankapazitanz (C) bewirkt. Durch diese Anordnung kann man die Ladezeit auf einen Wert senke, der wesentlich unter der Zeitkonstanten (R sC) liegt.

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Eriksson, N.E., Sandblom, J. & Hägglund, J. A voltage clamp circuit for measuring rapid current transients in membranes. Med. & biol. Engng. 14, 334–338 (1976). https://doi.org/10.1007/BF02478132

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  • DOI: https://doi.org/10.1007/BF02478132

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