Abstract
Two equations have been developed that describe the interrelationship of the clinically measurable variables of the human systemic arterial system. An approximation method is given for their simultaneous solution for systolic and diastolic pressures in terms of heart rate, cardiac output, total peripheral resistance, and aortic distensibility. In this way, blood pressures were calculated for various clinically important and didactically useful situations. The effects on systolic and diastolic pressures due to changing either cardiac output or peripheral resistance or heart rate or aortic distensibility alone are shown. The effects on pulse pressure of varying cardiac output and peripheral resistance while holding mean arterial pressure constant are demonstrated. Compensatory mechanisms in hypertension and exercise are explored.
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Opinions and conclusions contained in this report are those of the author. They are not to be construed as necessarily reflecting the views or the endorsement of the Navy Department.
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Cope, F.W. A method for calculation of human systolic and diastolic blood pressures using an elastic reservoir theory of the systemic arterial system, and some clinical and physiological applications. Bulletin of Mathematical Biophysics 24, 137–157 (1962). https://doi.org/10.1007/BF02477423
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DOI: https://doi.org/10.1007/BF02477423