Skip to main content
SpringerLink
Log in

The effectiveness of a combination of etoposide/adriamycin/cisplatin (EAP) against inoperable gastric cancer —Report of a histologically proven case—

  • Case Reports
  • Published:
The Japanese journal of surgery Aims and scope Submit manuscript

Abstract

We report herein, the histological observations taken at initial laparotomy from a 55 year old man with unresectable gastric cancer who responded almost completely to chemotherapy with Etoposide/Adriamycin/Cisplatin (EAP). The patient underwent a second operation after 2 cycles of EAP therapy and the stomach and adjacent lymph nodes were successfully resected. Histologic findings showed that cancer cells in the main tumor including the site of direct invasion had completely disappeared and been replaced by regenerated mucosa. The metastatic lymph node tumor was also partially killed, as indicated by a cluster of viable cancer cells which was divided by a strip of necrotic tissue. These findings led us to conclude that EAP therapy was remarkably effective for the patient.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Preusser P, Wilke H, Achterrath W, Neuhaus B, Balleisen L, Meyer J, Vandeloo J. Advanced inoperable stomach cancer: a pilot study with the combination Etoposide, Adriamycin and Cisplatin. Anticancer Res 1986; 6: 1195–1196.

    PubMed  CAS  Google Scholar 

  2. Preusser P, Wilke H, Achterrath W, Fink U, Meyer J, Meyer HG, Loo J. Phase-II-Studie mit Etoposid, Adriamycin, Cisplatin (EAP) beim primaer inoperablen, metastasierten Magenkarzinom. Tumor Diagnostik & Therapie 1987; 8: 43–48.

    Google Scholar 

  3. Comis RL, Carter SK. A review of chemotherapy in gastric cancer. Cancer 1974; 34: 1576–1586.

    Article  PubMed  CAS  Google Scholar 

  4. Moertel CG, Lavin PT. Phase II–III chemotherapy studies in advanced gastric cancer. Cancer Treat Rep 1979; 63: 1863–1869.

    PubMed  CAS  Google Scholar 

  5. Lawrence L, McDonald B, Dindogru A, Samson M, Vaitkevicius VK. Cisplatin—An active drug in the treatment of disseminated gastric cancer. Cancer 1984; 53: 18–22.

    Article  Google Scholar 

  6. Kelsen DP, Magill GB, Cheng E, Dukeman M, Sordillo P, Heelan R, Yagoda A. Phase II trial of etoposide in adenocarcinoma of the gastrointestinal tract. Cancer Treatment Reports 1983; 67: 509–510.

    PubMed  CAS  Google Scholar 

  7. Vogl SE, Engstrom PF. Cisplatin, doxorubicin, and 5-FU in combination for advanced gastric cancer. Cancer Treat Rep 1984; 68: 1273–1275.

    PubMed  CAS  Google Scholar 

  8. Wegenar DJ, Yap SH, Wobbes T, Burghous JTM, Dam FE, Hillen HFP, Hoogendoorn GJ, Scheerder H, Vegt SGL. Phase II trial of 5-fluorouracil, adriamycin and cisplatin (FAP) in advanced gastric cancer. Cancer Chemother Pharmacol 1985; 15: 86–87.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Department of Surgery II, Osaka University Medical School, 1-1-50, Fukushima, Fukushima-ku, 553, Osaka, Japan

    Hideaki Tahara MD, Michio Ogawa, Yoshihiro Kido, Hitoshi Shiozaki, Ichirou Ohashi & Takesada Mori

  2. The Department of Pathology, Osaka University Hospital, Osaka, Japan

    Masami Sakurai

Authors
  1. Hideaki Tahara MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Michio Ogawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yoshihiro Kido
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hitoshi Shiozaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ichirou Ohashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Takesada Mori
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Masami Sakurai
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tahara, H., Ogawa, M., Kido, Y. et al. The effectiveness of a combination of etoposide/adriamycin/cisplatin (EAP) against inoperable gastric cancer —Report of a histologically proven case—. The Japanese Journal of Surgery 21, 433–437 (1991). https://doi.org/10.1007/BF02470971

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02470971

Key Words

Search

Navigation