The Japanese journal of surgery

, Volume 21, Issue 2, pp 193–200 | Cite as

Evaluation of a new calcium containing cardioplegic solution in the isolated rabbit heart in comparison to a calcium-free, low sodium solution

  • Fumiki Mori
  • Kazuhiro Suzuki
  • Hiroshi Noda
  • Tomoe Kato
  • Hidetoshi Tsuboi
  • Masaki Miyamoto
  • Kensuke Esato
  • Akihisa Imamura
  • Seiji Kawahara
  • Junko Uchiyama
  • Noboru Kamiya
Original Articles

Abstract

Isolated perfused rabbit hearts were studied to compare the effects of 3 hour ischemic arrest following either calcium-free or calcium-containing cardioplegia, on the recovery of isovolumic function of the left ventricle, coronary flow, release of creatine phosphokinase and myocardial water content. The hearts perfused with the calcium-containing solution (Ca 0.5 mmol/L) showed better recovery of the developed pressure in the left ventricle, and its first derivative and compliance. Coronary flow at a constant perfusion pressure was better restored during reperfusion in the hearts with calcium-containing solution. The release of less CPK and a lower water content were also observed in the hearts reperfused with calcium-containing solution. We concluded that calcium-containing cardioplegic solution with a high concentration of magnesium (10 mmol/L) was superior to calcium-free solution for myocardial protection.

Key Words

calcium magnesium cardioplegic solution 

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Copyright information

© The Japan Surgical Society 1991

Authors and Affiliations

  • Fumiki Mori
    • 1
  • Kazuhiro Suzuki
    • 1
  • Hiroshi Noda
    • 1
  • Tomoe Kato
    • 1
  • Hidetoshi Tsuboi
    • 1
  • Masaki Miyamoto
    • 1
  • Kensuke Esato
    • 1
  • Akihisa Imamura
    • 2
  • Seiji Kawahara
    • 2
  • Junko Uchiyama
    • 2
  • Noboru Kamiya
    • 2
  1. 1.Department of PharmacyYamaguchi University School of MedicineUbe, YamaguchiJapan
  2. 2.The First Department of SurgeryYamaguchi University School of MedicineUbe, YamaguchiJapan

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