Abstract
In 501 Japanese patients with gastric cancer, the relationships between preoperative lymphocyte proliferative (LP) responses to mitogens and prognosis of patients were evaluated. Peripheral blood lymphocytes were cultured in the presence of either autologous or allogeneic serum and their LP responses to phytohemagglutinin (PHA) and pokeweed mitogen were investigated. An apparent inverse relationship between LP responses and stage of the disease was found in LP responses to PHA in the presence of autologous serum. The survival rate of patients with higher responses was significantly greater than of those with lower responses, when LP responses to PHA in the presence of autologous serum served as the criterion. Probabilities of staging which were computed on the basis of LP response to PHA affirmed the reciprocal relationship between LP responses and stage of the disease. From these results, it is concluded that evaluation of LP responses may be a valuable tool in the assessment of the clinical stage and in the prediction of prognosis.
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References
Research Society for Gastric Cancer: The general rules for gastric cancer study in surgery and pathology. Jpn. J. Surg. 11: 127–139, 1981.
Toge, T., Ikeda, H., Senoo, N., Niimoto, M. and Hattori, T.: Lymphocyte responsiveness to phytohemagglutinin (PHA) and serum inhibitory effect in patients with gastric cancer. Jpn. J. Surg. 6: 157–163, 1976.
Dean, J.H., Cannon, R., Herberman, R.B., Silva, J., McCoy, J.L. and Oldham, R.K.: The relative proliferation index as a more sensitive parameter for evaluating lymphoproliferative responses of cancer patients to mitogens and alloantigen. Int. J. Cancer 20: 359–370, 1977.
Toge, T., Nagusa, Y., Nakano, A., Ikeda, H. and Hattori, T.: Lymphocyte responsiveness to phytohemagglutinin and its modulation by serum inhibitor in breast cancer patients. Gann 70: 245–248, 1979.
Cosini, A.B., Brunstetter, F.H., Kemmerer, W.T. and Miller, R.N.: Cellular immune competence of breast cancer patients receiving radiotherapy. Arch. Surg. 107: 531–535, 1973.
Chretien, P.B., Crowder, W.L., Gertner, H.R., Sample, W.F. and Catalona, W.J.: Correlation of preoperative lymphocyte reactivity with the clinical course of cancer patients. Surg. Gynecolo. Obstet. 136: 380–384, 1973.
Vilien, M., Wolf, H. and Rasmussen, F.: Follow-up investigations of bladder cancer patients by titration of natural and specific lymphocyte mediated cytotoxicity. Prognostic significance of specific reactivity. Cancer Immunol. Immunother. 10: 171–180, 1981.
Dellon, A.L., Potvin, C. and Chretien, P.B.: Thymus dependent lymphocyte levels in bronchogenic carcinoma: Correlations with histology, clinical stage and clinical course after surgical treatment. Cancer 35: 687–694, 1975.
Wanebo, H.J., Rosen, P.P., Thaler, T., Urban, J.A. and Oettgen, H.F.: Immunobiology of operable cancer: An assessment of biologic risk of immunoparameters. Ann. Surg. 184: 258–267, 1976.
Cannon, G.B., Dean, J.H., Herberman, R.B., Perlin, E., Reid, J., Miller, C. and Lang, N.P.: Association of depressed postoperative lymphoproliferative responses to alloantigen with poor prognosis in patients with Stage I lung cancer. Int. J. Cancer 25: 9–17, 1980.
Arrons, S. T., Williams, A.A., Harris, R.E. and Orgen, C.H.: The peripheral lymphocyte count as an aid in the clinical staging of lung cancer. Ann. Surg. 187: 248–250, 1978.
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Toge, T., Oride, M., Yanagawa, E. et al. Prognostic significance of lymphocyte proliferative responses to mitogens in gastric cancer patients. The Japanese Journal of Surgery 12, 424–428 (1982). https://doi.org/10.1007/BF02469832
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DOI: https://doi.org/10.1007/BF02469832