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Evaluation of chemotherapeutic effects on gastric cancer in relation to the histological pattern

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Summary

A combination of MFC (Mitomycin-C, 5-FU and Cytosine arabinoside) was administered to 32 gastric cancer patients and study was made of the therapeutic efficacy in relation to the histological pattern.

In evaluation based on the degree of cancer cell infiltration (INF), chemotherapy was more effective in cases with INF α and β than those with INF γ. As for the grade of follicular hyperplasia in regional lymph nodes of gastric cancer, the higher was the grade, the more effective was the chemotherapy.

However, a significant relationship could not be observed between histological pattern of stromal reaction of the gastric cancer and clinical effects of chemotherapy. The grade of lymphocyte infiltration or connective tissue reaction in the stroma was not related with the therapeutic effects. No relationship was also obtained between the grade of sinus histiocytosis of lymphoid reaction in the lymph nodes and therapeutic effects.

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Authors and Affiliations

  1. Department of Surgery, Research Institute for Nuclear Medicine and Biology, Hiroshima University, Hiroshima, Japan

    Minoru Niimoto, Shisei Yamagata, Tetsuya Toge, Tatsuji Harada, Hiroshi Ikeda & Takao Hattori

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  1. Minoru Niimoto
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  2. Shisei Yamagata
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  3. Tetsuya Toge
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  4. Tatsuji Harada
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  5. Hiroshi Ikeda
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  6. Takao Hattori
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Niimoto, M., Yamagata, S., Toge, T. et al. Evaluation of chemotherapeutic effects on gastric cancer in relation to the histological pattern. The Japanese Journal of Surgery 8, 1–9 (1978). https://doi.org/10.1007/BF02469329

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  • DOI: https://doi.org/10.1007/BF02469329

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