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Inhibitory mechanisms of insulin secretion associated with hyothermic open-heart surgery

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Abstract

In order to clarify the inhibitory mechanism of insulin secretion associated with open-heart surgery, the influence of insulin antagonistic hormones on insulin secretion was studied in 20 patients with congenital heart diseases undergoing open-heart surgery, under simple deep hypothermia. Despite a hyperglycemia, plasma immunoreactive insulin and C-peptide showed no change during the cooling period, while with the exception of plasma human growth hormone, dopamine-β-hydroxylase, immunoreactive glucagon, cortisol and cyclic AMP in plasma, either showed no change, or a decrease during the cooling period. It is assumed that catecholamine, glucocorticoid and glucagon do not play an important role in the inhibitory mechanism of insulin secretion during hypothermic open-heart surgery, and a transient hypofunction of the pancreas as well as the liver and the adrenal gland is probably involved.

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Authors and Affiliations

  1. The Second Department of Surgery, Research Laboratory for Cardiovascular Diseases, Shinshu University School of Medicine, 390, Matsumoto City, Nagano, Japan

    Hiroshi Shida

  2. The Second Department of Surgery, Shinshu University School of Medicine, 390, Matsumoto City, Nagano, Japan

    Masami Morimoto

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  1. Hiroshi Shida
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  2. Masami Morimoto
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  3. Koichi Inokawa
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  4. Yutaka Ikeda
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Shida, H., Morimoto, M., Inokawa, K. et al. Inhibitory mechanisms of insulin secretion associated with hyothermic open-heart surgery. The Japanese Journal of Surgery 11, 67–72 (1981). https://doi.org/10.1007/BF02468871

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  • DOI: https://doi.org/10.1007/BF02468871

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