Skip to main content
SpringerLink
Log in

Reactive hyperplasia of paracortex and germinal centers of the regional lymph nodes in gastric carcinoma cases as a favorable prognostic indicator

  • Published:
The Japanese journal of surgery Aims and scope Submit manuscript

Abstract

The prognosis of 141 patients subjected to curative resection for gastric carcinoma was analyzed with special reference to the paracortex, germinal centers and sinus histiocytes in the regional lymph nodes. Five year survival rates of the patients with paracortical and/or germinal center hyperplasia (PH and/or GH) was definitely superior to those without such hyperplasia. This difference was most pronouced in those with moderately advanced stage. The incidence of lymph node metastasis was lower in the patients with PH or GH. The presence of sinus histiocytosis (SH) seemed to be correlated neither with a longer survival nor with lower incidence of lymph node metastasis. No close correlation was found between Ph, GH and SH on one hand and histological types of the primary gastric carcinomas on the other. These results suggest that cell mediated and/or humoral immune response may play an important role in host resistance against gastric carcinoma.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Bard, D.S., Hammond, W.G., and Pilch, Y.H.: The role of the regional lymph nodes in the immunity to a chemically induced sarcoma in C3H mice. Cancer Res. 29: 1379–1384, 1969.

    PubMed  CAS  Google Scholar 

  2. Berg, J.W.: Sinus histiocytosis—A fallacious measure of host resistance to cancer. Cancer 9: 935–939, 1956.

    Article  PubMed  CAS  Google Scholar 

  3. Berg, J.W.: Inflammation and prognosis in breast cancer. A search for host resistance. Cancer 12: 714–720, 1959.

    Article  PubMed  CAS  Google Scholar 

  4. Black, M.M., Kerpe, S., and Speer, F.D.: Lymph node structure in patients with cancer of the breast. Amer. J. Path. 24: 505–521, 1953.

    Google Scholar 

  5. Black, M.M., Opler, S.R., and Speer, F.D.: Microscopic structure of gastric carcinomas and their regional lymph nodes in relation to survival. Surg. Gynec. Obstet. 98: 725–734, 1954.

    PubMed  CAS  Google Scholar 

  6. Black, M.M.: Reactivity of the lymphoreticuloendothelial system in human cancer. Progr. Clin. Cancer 1: 26–49, 1965.

    Google Scholar 

  7. Black, M.M., Freeman, C., Mork, T., Harvei, S., and Cutler, S.: Prognostic significance of microscopic structure of gastric carcinoma and their regional lymph nodes. Cancer 27: 703–711, 1972.

    Article  Google Scholar 

  8. Coley, W.B.: Contribution to the knowledge of sarcoma. Ann. Surg. 14: 199–220, 1891.

    Google Scholar 

  9. Cottier, H., Turk, J., and Sabin, L.: A proposal for a standardized system of reporting human lymph node morphology in relation to immunologic function. WHO Bull. 47: 375–408, 1972.

    CAS  Google Scholar 

  10. Crile, G. Jr.: Rationale of simple mastectomy without radiation for clinical stage 1 cancer of the breast. Surg. Gynec. Obstet. 120: 975–982, 1965.

    PubMed  Google Scholar 

  11. Crile, G., Jr.: The place of lymph adenectomy in cancer surgery. Lymphology 5: 89–93, 1972.

    PubMed  Google Scholar 

  12. Fisher, B., and Fisher, E.R.: Studies concerning the regional lymph node in cancer. I, Initiation of immunity. Cancer 27: 1001–1004, 1971.

    Article  PubMed  CAS  Google Scholar 

  13. Fisher, B., and Fisher, E.R.: Studies concerning the regional lymph node in cancer. II, Maintenace of immunity. Cancer 29: 1496–1500, 1972.

    Article  PubMed  CAS  Google Scholar 

  14. Futrell, J.W., and Pories, W.J.: Physiologic and immunologic considerations of the lymphatic system in tumors and transplants. Surg. Gynec. Obstet. 140: 273–292, 1975.

    PubMed  CAS  Google Scholar 

  15. Haagensen, C.D., Feird, C.R., Herter, F.P., and other: The lymphatics in cancer. Philadelphia, W.B. Saunders Co., 1972.

    Google Scholar 

  16. Halpern, B.N., Biozzi, G., Stiffel, C., and Mouton, D.: Inhibition of tumor growth by administration of killed corynebacterium parvum. Nature 212: 853–854, 1966.

    Article  PubMed  CAS  Google Scholar 

  17. Hellström, I., and Hellstrom, K.E.: New concepts of carcinoma of colon and rectum-Cellular immunity of human colonic carcinoma. Dis. Colon. Rectum. 15: 100–105, 1972.

    PubMed  Google Scholar 

  18. Hunter, R.L., Fergusson, D.J., and Coppleson, L.W.: Survival with mammary carcinoma related to germinal center hyperplasia and sinus histiocytosis in axillary and internal mammary lymph nodes. Cancer 35: 528–539, 1975.

    Article  Google Scholar 

  19. Imai, T.: Growth patterns in human carcinoma. Their classification and relation to prognosis. Obstet. Gynec. 16: 296–308, 1960.

    PubMed  CAS  Google Scholar 

  20. Inokuchi, K., Inutsuka, S., Furusawa, M., Soejima, K., and Ikeda, T.: Stromal reaction around tumor and metastasis and prognosis after curvative gastrectomy for carcinoma of the stomach. Cancer 20: 1924–1929, 1967.

    Article  PubMed  CAS  Google Scholar 

  21. Japanese Research Society for Gastric Cancer: The General Rules for the Gastric Cancer Study in Surgery. Jap. J. Surg. 3: 61–71, 1973.

    Article  Google Scholar 

  22. Kroman, B., Shapiro, H., and Localio, S.A.: Delayed hypersensitivity responses of patients with carcinoma of the colon and other solid tumors. Dis. Colon. Rectum 15: 106–110, 1972.

    Google Scholar 

  23. MacCarty, W.C.: Factors which influence longevity in cancer-A study of 293 cases. Ann. Surg. 76: 9–12, 1922.

    Google Scholar 

  24. Mitchison, N.A.: Studies on the immunological response to foreign tumor transplants in the mouse. I, The role of lymph node cells in conferring immunity by adoptive transfer. J. Exp. Med. 162: 157–177, 1955.

    Article  Google Scholar 

  25. Old, L.J., Benacerraf, B., Clarke, D.A., Carswell, E.A., and Stockert, E.: The role of the reticuloendothelial system in the host reaction to neoplasia. Cancer Res. 21: 1281–1300, 1961.

    PubMed  CAS  Google Scholar 

  26. Patt, D.J., Brynes, R.K., Vardiman, J.W., and Coppleson, L.W.: Mesocolic lymph node histology is an important prognostic indicator for patients with carcinoma of the sigmoid colon: an immunomorphological study. Cancer 35: 1388–1397, 1975.

    Article  PubMed  CAS  Google Scholar 

  27. Ree, H., and Franger, H.: Paracortical alteration in lymphadenopathic and tumor-draining lymph nodes: Histologic study. Human Path. 6: 363–372, 1975.

    CAS  Google Scholar 

  28. Soloway, M.S., Pendergrast, W.J., and Meyers, G.H.: The regional lymph nodes and concomitant immunity. Surg. Forum 23: 101–102, 1972.

    PubMed  CAS  Google Scholar 

  29. Toyoshima, S., and Enjoji, M.: Histological representations of host resistance in mammary carcinoma. Fukuoka Igakuzasshi (Fukuoka Acta Medica) 66: 387–396, 1975. (in Japanese).

    CAS  Google Scholar 

  30. Tsakraklides, V., Anastassiades, O.T., and Kersey, J.H.: Prognostic significance of regional lymph node histology in uterine cervical cancer. Cancer 31: 860–868, 1973.

    Article  PubMed  CAS  Google Scholar 

  31. Turk, J.L., and Oort, A.: The production of sensitized cells in cell-mediated immunity. In: Handbuch der Allgemeine Pathologie VII/3 Immunreaktionen. edited by Altmann, H.W., and others Berlin-Heiderberg-New York. Springer-Verlag, 1970, pp. 392–435.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Second Department of Surgery, Kyushu University, Faculty of Medicine, Fukuoka, Japan

    Yoshifumi Kodama & Kazuhiko Soejima

  2. the Second Department of Surgery, Kyushu University, Faculty of Medicine, Fukuoka, Japan

    Kiyoshi Inokuchi

Authors
  1. Yoshifumi Kodama
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kazuhiko Soejima
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kiyoshi Inokuchi
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kodama, Y., Soejima, K. & Inokuchi, K. Reactive hyperplasia of paracortex and germinal centers of the regional lymph nodes in gastric carcinoma cases as a favorable prognostic indicator. The Japanese Journal of Surgery 6, 9–18 (1976). https://doi.org/10.1007/BF02468614

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02468614

Key Words

Search

Navigation