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Achievements and prospects in the creation of antiaggregative drugs (Review)

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Conclusion

Achievements in medicinal chemistry and pharmacology in studying the mechanisms of action of antiaggregants provide a deeper insight into the physicochemical backgrounds of phenomena involved in thrombocyte aggregation and provide controls for these processes using inductors and inhibitors of aggregation.

The information gained from experiments indicates the promising directions in the search for new, more efficient antithrombotic drugs. Good prospects are also related to the synthesis and search for inhibitors of various anzymes controlling the energetics of thrombocytes and capable of affecting their functional activity.

At present, a number of compounds capable of inhibiting the reactions of serotonin, fibrinogen, and thrombin, and combinations of serotonin and thromboxan inhibitors, are in various stages of characterization and implementation into practice.

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Authors and Affiliations

  1. A. V. Bogatskii Institute of Physical Chemistry, National Academy of Sciences of Ukraine, Odessa, Ukraine

    S. A. Andronati & T. L. Karaseva

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  1. S. A. Andronati
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  2. T. L. Karaseva
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 31, No. 3, pp. 3–9, March, 1997.

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Andronati, S.A., Karaseva, T.L. Achievements and prospects in the creation of antiaggregative drugs (Review). Pharm Chem J 31, 109–115 (1997). https://doi.org/10.1007/BF02464660

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