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In silico consensus activity prediction, rational synthesis, and evaluation of antiglycation and antiplatelet activities of 3,6-disubstituted 1,2,4,5-tetrazines

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Abstract

According to the in silico consensus activity prediction, a series of 3,6-disubstituted 1,2,4,5-tetrazines were synthesized as promising inhibitors of the Maillard reaction. In addition to the studies of antiglycation activity, a comparative in vitro evaluation of the effect of the synthesized compounds on the ADP-induced rabbit platelet aggregation model was carried out. Compounds with antiglycation and antiplatelet activities significantly higher than that of the reference drugs, aminoguanidine and acetylsalicylic acid, were revealed.

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Authors and Affiliations

  1. I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 ul. S. Kovalevskoy, 620137, Ekaterinburg, Russian Federation

    R. I. Ishmetova, N. K. Ignatenko, S. G. Tolschina & G. L. Rusinov

  2. Volgograd State Medical University, Ministry of Health of Russian Federation, 1 pl. Pavshikh Bortsov, 400131, Volgograd, Russian Federation

    D. A. Babkov, A. F. Kucheryavenko, V. A. Babkova, V. S. Sirotenko, P. M. Vassiliev & A. A. Spasov

  3. Ural State Technical University named after the first President of Russia B. N. Yeltshin, 19 ul. Mira, 620002, Ekaterinburg, Russian Federation

    G. L. Rusinov

Authors
  1. R. I. Ishmetova
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  2. D. A. Babkov
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  3. A. F. Kucheryavenko
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  4. V. A. Babkova
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  5. V. S. Sirotenko
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  6. N. K. Ignatenko
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  7. S. G. Tolschina
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  8. P. M. Vassiliev
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  9. G. L. Rusinov
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  10. A. A. Spasov
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Corresponding author

Correspondence to R. I. Ishmetova.

Additional information

This work was financially supported by the Ministry of Science and Higher Education of the Russian Federation (State task No. AAAA-A19-119011790134-1) and performed using the equipment of the Shared Access Center for Spectroscopy and Analysis of Organic Compounds of the Ural Branch of RAS.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 4, pp. 0768–0773, April, 2020.

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Ishmetova, R.I., Babkov, D.A., Kucheryavenko, A.F. et al. In silico consensus activity prediction, rational synthesis, and evaluation of antiglycation and antiplatelet activities of 3,6-disubstituted 1,2,4,5-tetrazines. Russ Chem Bull 69, 768–773 (2020). https://doi.org/10.1007/s11172-020-2831-6

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  • DOI: https://doi.org/10.1007/s11172-020-2831-6

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