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Effect of stimulation of the lateral hypothalamus on the correlation of neuron spike activity in the rabbit neocortex

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Abstract

Cross-correlation and autocorrelation histograms were constructed with the aim of studying correlated spike activity of neurons in the visual and sensorimotor regions of both hemispheres of the rabbit brain before and after stimulation of the right and left lateral hypothalamic regions, which generates food-motivated responses. Stimulation of the left hypothalamus produced larger rearrangements in correlated neuron firing than stimulation of the right hypothalamus. Stimulation of the left hypothalamus, unlike that of the right hypothalamus, was followed by significant increases in the numbers of pairs of left hemisphere neocortical neurons with linked activity, and also induced the sequential firing of neurons in a particular defined order: sensorimotor cortex cells fired first, followed by visual cortex neurons after delays of up to 120 msec. It is concluded that cortical interhemisphere asymmetry in conditions of hunger is associated with nonuniform functioning of the right and left lateral hypothalamic regions.

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References

  1. É. A. Asratyan, “Reflex mechanisms of motivational behavior,” in: The Reflex Theory of Higher Nervous Activity: Selected Papers [in Russian], Nauka, Moscow (1983), p. 282.

    Google Scholar 

  2. O. G. Baklavadzhyan and V. S. Eganova, “Neuronal mechanisms of hypothalamo-reticular influences on cortical activity,” Usp. Fiziol. Nauk,13, No. 2, 3 (1982).

    Google Scholar 

  3. V. L. Bianki, S. É. Murik, and E. B. Filippova, “Interhemispherice asymmetry of positive emotional responses in rats,” Zh. Vyssh. Nerv. Deyat.,38, No. 4, 693 (1988).

    CAS  Google Scholar 

  4. V. G. Zilov, Comparative Characteristics of Cortico-Subcortical Interactions in the Structure of Motivations of Different Biological Qualities [in Russian], Author's Abstract of Thesis for Doctorate in Medical Sciences, P. K. Anokhin Science Research Institute of Normal Physiology, Moscow (1978).

    Google Scholar 

  5. I. V. Pavlova, Interactions of Neocortical Neurons in Tonic Conditioned Reflexes [in Russian], Nauka, Moscow (1990).

    Google Scholar 

  6. I. V. Pavlova, “Interactions of neocortical neurons in rabbits in conditions of natural food motivation,” Zh. Vyssh. Nerv. Deyat.,46, No. 1, 108 (1996).

    CAS  Google Scholar 

  7. I. V. Pavlova, I. V. Volkov, and V. N. Mats, “The effects of stimulation of the medial hypothalamus on interactions of neurons in the rabbit neocortex,” Zh. Vyssh. Nerv. Deyat.,45, No. 2, 344 (1995).

    Google Scholar 

  8. I. V. Pavlova and V. N. Mats, “Functional asymmetry of the lateral hypothalamus of the rabbit in conditions of food motivation,” Zh. Vyssh. Nerv. Deyat.,46, No. 4, 740 (1996).

    CAS  Google Scholar 

  9. R. A. Pavlygina and Yu. V. Lyubimova, “Spectral characteristics of brain electrical activity in the rabbit in the state of hunger,” Zh. Vyssh. Nerv. Deyat.,44, No. 1, 57 (1994).

    CAS  Google Scholar 

  10. R. A. Pavlygina and Yu. V. Lyubimova, “Correlational characteristics of the electrical activity of the rabbit brain in the state of hunger,” Zh. Vyssh. Nerv. Deyat.,44, No. 3, 532 (1994).

    CAS  Google Scholar 

  11. R. A. Pavlygina, A. V. Sulimov, and L. A. Zhavoronkova, “Interhemisphere relationships of the EEG in conditions of a hunger dominant in humans (coherent analysis),” Dokl. Rus. Akad. Nauk,338, No. 6, 833 (1994).

    CAS  Google Scholar 

  12. E. S. Petrov, T. M. Makarova, A. A. Lebedev, and G. A. Vartanyan, “The emotional properties of symmetrical parts of the lateral hypothalamus in rats reared in communities and in isolation,” Zh. Vyssh. Nerv. Deyat,38, No. 3, 553 (1988).

    CAS  Google Scholar 

  13. P. V. Simonov, The Motivated Brain [in Russian], Nauka, Moscow (1987).

    Google Scholar 

  14. P. V. Simonov, M. N. Rusalova, L. A. Preobrazhenskaya, and G. L. Vanetsian, “The novelty factor and functional asymmetry of the brain,” Zh. Vyssh. Nerv. Deyat.,45, No. 1, 13 (1995).

    CAS  Google Scholar 

  15. K. V. Sudakov, Biological Motivations [in Russian], Meditsina, Moscow (1971).

    Google Scholar 

  16. K. V. Sudakov, B. V. Zhuravlev, A. A. Kromin, et al., “Reflection of the dominant motivation in the activity of neurons of the brain and peripheral organs,” Usp. Fiziol. Nauk,19, No. 3, 24 (1988).

    PubMed  CAS  Google Scholar 

  17. S. K. Sudakov, “Molecular mechanisms of the involvement of pyramidal neurons of the sensorimotor cortex of the brain in the organization of feeding behavior in rabbits,” Neirofiziologiya,19, No. 5, 601 (1987).

    CAS  Google Scholar 

  18. I. P. Tsvetkova, The Rabbit Hypothalamus. A Stereotaxic and Cytoarchitectonic Atlas [in Russian], Nauka, Leningrad (1978).

    Google Scholar 

  19. B. K. Anand and J. N. Brobek, “Localization of a feeding center in the hypothalamus of the rat,” Proc. Soc. Exp. Biol. Med.,77, 323 (1951).

    PubMed  CAS  Google Scholar 

  20. S. D. Glick, L. M. Weaver, and R. C. Meibach, “Lateralization of reward in rats: differences in reinforcing thresholds,” Science,207, No. 4435, 1093 (1980).

    PubMed  CAS  Google Scholar 

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Authors
  1. I. V. Pavlova
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  2. I. V. Volkov
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  3. V. N. Mats
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Additional information

Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow. Translated from Fiziologicheskii Zhurnal Vysshei Nervnoi Deyatel'nosti, Vol. 46, No. 6, pp. 1068–1075, November–December, 1996.

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Pavlova, I.V., Volkov, I.V. & Mats, V.N. Effect of stimulation of the lateral hypothalamus on the correlation of neuron spike activity in the rabbit neocortex. Neurosci Behav Physiol 28, 167–173 (1998). https://doi.org/10.1007/BF02461963

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  • DOI: https://doi.org/10.1007/BF02461963

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