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Ising model forB-Z transition in supercoiled DNA

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Abstract

The possible existence of nucleic acids in right-handed and left-handed helical forms is considered. A statistical mechanical model is developed to obtain an expression for a change in twist during helical transformation in terms of corresponding free energies and linking for a supercoiled DNA. The theoretically predicted values are compared with those determined experimentally. The physico-chemical significance of the parameters is discussed.

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Authors and Affiliations

  1. Department of Biophysics, University of Delhi South Campus, 110021, New Delhi, India

    Subhendu Ghosh

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  1. Subhendu Ghosh
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Ghosh, S. Ising model forB-Z transition in supercoiled DNA. Bltn Mathcal Biology 54, 727–732 (1992). https://doi.org/10.1007/BF02459927

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  • DOI: https://doi.org/10.1007/BF02459927

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