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Calmodulin in osteogenic sarcoma

  • Oncology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The content of calmodulin in homogenates prepared from various morphological variants of primary osteogenic sarcoma varies fromn 408 to 14,255 ng/mg total protein and is lowered by neoadjunctive chemotherapy. The 5-year incidence of metastases is lower when the calmodulin content in the tumor is>6000 ng/mg protein. At calmodulin content<6000 ng/mg protein, the occurrence of metastases is lower in patients receiving neoadjunctive therapy before surgery than in untreated patients.

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Authors and Affiliations

  1. N. N. Blokhin Oncology Research Center, Russian Academy of Medical Sciences, Moscow

    N. E. Kushlinskii, N. N. Trapeznikov, P. V. Sergeev, Yu. N. Solov'ev, M. D. Shikhammedov, I. V. Babkina, S. A. Chukaev & Ch. M. Kasumov

  2. Russian State Medical University, Moscow

    N. E. Kushlinskii, N. N. Trapeznikov, P. V. Sergeev, Yu. N. Solov'ev, M. D. Shikhammedov, I. V. Babkina, S. A. Chukaev & Ch. M. Kasumov

Authors
  1. N. E. Kushlinskii
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  2. N. N. Trapeznikov
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  3. P. V. Sergeev
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  4. Yu. N. Solov'ev
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  5. M. D. Shikhammedov
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  6. I. V. Babkina
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  7. S. A. Chukaev
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  8. Ch. M. Kasumov
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 123, No. 6, pp. 690–692, June, 1997

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Kushlinskii, N.E., Trapeznikov, N.N., Sergeev, P.V. et al. Calmodulin in osteogenic sarcoma. Bull Exp Biol Med 123, 599–600 (1997). https://doi.org/10.1007/BF02458090

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  • DOI: https://doi.org/10.1007/BF02458090

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