Abstract
The alternative and graduated methods for estimation of fast-reversible effects of ethanol are compared. Estimation of the myorelaxing and anticonvulsive effects of ethanol by the alternative method can be used with some limitations for the effector analysis of ethanol pharmacokinetics. It is shown that the effector expectation of pharmacokinetic profile for ethanol based on the minimal effective doses of bicuculline inducing clonic convulsions and tonic extension is comparable to experimentally determined brain contents of14C-ethanol.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
T. A. Voronina, Yu. I. Vikhlyaev, L. N. Nerobkova,et al., in:Phenazepam [in Russian], Kiev (1982), pp. 87–181.
N. Ya. Golovenko, V. G. Zin'kovskii, O. V. Zhuk, and E. A. Stankevich, in:Gidazepam [in Russian], Kiev (1992), pp. 20–50.
V. G. Zin'kovskii, O. V. Zhuk, and N. Ya. Golovenko, in:Mechanisms of Action of Anxiolytic, Anticonvulsive, and Soporific Drugs [in Russian], Kiev (1988), pp. 98–175.
N. A. Plokhinskii,Algorithms of Biometry [in Russian], Moscow (1980).
V. N. Solov'ev, A. A. Firsov, and V. A. Filov,Pharmacokinetics [in Russian], Moscow (1980).
L. Singh, R. J. Oles, C. A. Vass, and G. N. Woodruff,J. Neurosci. Methods,37, 227–232 (1991).
Author information
Authors and Affiliations
Additional information
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 123, No. 6, pp. 673–676, June, 1997
Rights and permissions
About this article
Cite this article
Zhuk, M.S., Zin'kovskii, V.G., Zhuk, O.V. et al. Estimation fast-reversible of effects of ethanol and pharmacokinetic forecast. Bull Exp Biol Med 123, 585–587 (1997). https://doi.org/10.1007/BF02458085
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02458085