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Role of mast cells in regulation of erythropoiesis during inflammation

  • General Pathology and Pathological Physiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Using the mouse model of acute infectious peritonitis caused byEscherichia coli, we have shown that preliminary osmotic elimination of peritoneal mast cells markedly affects the erythron reaction and its mechanisms during inflammation. Activation of local regulatory mechanisms of erythropoiesis (hemopoiesis-inducing microenvironment) and less pronounced hyperplasia of the erythron in the bone marrow were noted.

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Authors and Affiliations

  1. Institute of Pharmacology, Tomsk Research Center, Russian Academy of Medical Sciences, Kharkov

    A. M. Dygai, B. Yu. Gumilevskii, E. V. Simanina, E. Yu. Sherstoboev & E. D. Gol'dberg

  2. State Medical University, Kharkov

    N. A. Klimenko

Authors
  1. N. A. Klimenko
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  2. A. M. Dygai
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  3. B. Yu. Gumilevskii
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  4. E. V. Simanina
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  5. E. Yu. Sherstoboev
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  6. E. D. Gol'dberg
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 123, No. 6, pp. 626–629, June, 1997

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Klimenko, N.A., Dygai, A.M., Gumilevskii, B.Y. et al. Role of mast cells in regulation of erythropoiesis during inflammation. Bull Exp Biol Med 123, 545–547 (1997). https://doi.org/10.1007/BF02458072

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  • DOI: https://doi.org/10.1007/BF02458072

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