Skip to main content
SpringerLink
Log in

Plasma interleukin-8, interleukin-10, and E-selectin levels in neutropenic and non-neutropenic bacteremic patients

  • Article
  • Published:
European Journal of Clinical Microbiology and Infectious Diseases Aims and scope Submit manuscript

Abstract

Plasma interleukin-8 (IL-8), interleukin-10 (IL-10), and E-selectin concentrations were studied in 39 neutropenic and 30 non-neutropenic bacteremic patients; 54 nonbacteremic patients were analyzed as controls. Interleukin-8 concentrations were significantly higher in neutropenic than in non-neutropenic bacteremic patients (median 475 vs. 0 pg/ml, p<0.0001). Median IL-8 and IL-10 levels were higher in bacteremic than in non-bacteremic patients (330 vs. 0 pg/ml, p<0.0001 and 20 vs. 0 pg/ml, p=0.04, respectively). In contrast, concentrations of IL-10 were similar in neutropenic and non-neutropenic patients. Median levels of E-selectin were not increased in any of the patient groups. Neutropenic bacteremic patients showed significantly lower concentrations of E-selectin than did non-neutropenic bacteremic patients (p<0.0001). In conclusion, neutropenic bacteremic patients had significantly higher concentrations of IL-8 than non-neutropenic bacteremic patients. Levels of IL-10 were higher in bacteremic than in nonbacteremic patients, but neutropenic and non-neutropenic patients had similar levels of IL-10. Increased levels of E-selectin were not found in any of the patient groups, although neutropenic patients with bacteremia had lower concentrations than did non-neutropenic patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Glauser MP, Heumann D, Baumgartner JD, Cohen J: Pathogenesis and potential strategies for prevention and treatment of septic shock: an update. Clinical Infectious Diseases 1994, 18, Supplement 2: 205–216.

    Google Scholar 

  2. Lawrence MB, Springer TA: Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequisite for adhesion through integrins. Cell 1991, 64: 1–20.

    Article  Google Scholar 

  3. Phillips ML, Nudelman E, Gaeta FCA, Perez M, Singhal AK, Hakomori S, Paulson JC: ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex. Science 1990, 250: 1130–1132.

    PubMed  CAS  Google Scholar 

  4. Baggiolini M, Walz A, Kunkel SL: Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils. Journal of Clinical Investigation 1989, 84: 1045–1049.

    Article  PubMed  CAS  Google Scholar 

  5. Van Zee KJ, DeForge LE, Fischer E, Marano M, Kenney JS, Remick DG, Lowry S, Moldawer LL: IL-8 in septic shock, endotoxemia and after IL-1 administration. Journal of Immunology 1991, 146: 3478–3482.

    Google Scholar 

  6. Hubere AR, Kunkel SL, Todd RF III, Weiss SJ: Regulation of transendothelial neutrophil migration by endogenous interleukin-8. Science 1991, 254: 99–102.

    Google Scholar 

  7. Marty C, Misset B, Tamion F, Fitting C, Carlet J, Cavailon J-M: Circulating interleukin-8 concentrations in patients with multiple organ failure of septic and nonseptic origin. Critical Care Medicine 1994, 22: 673–679.

    Article  PubMed  CAS  Google Scholar 

  8. Hack CE, Hart M, Strack van Schijndel RJM, Eerenberg AJM, Nuijens JH, Thijs LG, Aarden LA: Interleukin-8 in sepsis: relation to shock and inflammatory mediators. Infection and Immunity 1992, 60: 2835–2842.

    PubMed  CAS  Google Scholar 

  9. Hynninen M, Valtonen M, Vaara M, Markkanen H, Kuusela R, Saxen H, Takkunen O: Endotoxin and cytokine concentrations in neutropenic and non-neutropenic bacteremic patients. European Journal of Clinical Microbiology & Infectious Diseases 1996, 14: 1039–1045.

    Article  Google Scholar 

  10. Fiorentino DF, Zlotnik A, Mosmann TR: IL-10 inhibits cytokine production by activated macrophages. Journal of Immunology 1991, 147: 3815–3822.

    CAS  Google Scholar 

  11. Howard M, Muchamel T, Andrade S: lnterleukin-10 protects mice from lethal endotoxemia. Journal of Experimental Medicine 1993, 177: 547–550.

    Article  Google Scholar 

  12. Marchant A, Deviere J, Byl B, De Groote D, Vincent J-L, Goldman M: lnterleukin-10 production during septicaemia. Lancet 1994, 343: 707–708.

    Article  PubMed  CAS  Google Scholar 

  13. Derkx B, Marchant A, Goldman M, Bijlmer R, van Deventer S: High levels of interleukin-10 during the initial phase of fulminant meningococcal septic shock. Journal of Infectious Diseases 1995, 171: 229–232.

    PubMed  CAS  Google Scholar 

  14. Newman W, Beall LD, Carson CW, Hunder CG, Graben N, Randshawa ZI, Gopal TV, Wiener-Kronish J, Marhay MA: Soluble E-selectin is found in supernatants of activated endothelial cells and is elevated in the serum of patients with septic shock. Journal of Immunology 1993, 150: 644–654.

    CAS  Google Scholar 

  15. Adams DH, Shaw S: Leucocyte-endothelial interactions and regulation of leucocyte migration. Lancet 1994, 343: 830–836.

    Article  Google Scholar 

  16. Kuhns DB, Alvord WG, Gallin JI: Increased circulating cytokines, cytokine antagonists, and E-selectin after intravenous administration of endotoxin in humans. Journal of Infectious Diseases 1995, 171: 145–152.

    PubMed  CAS  Google Scholar 

  17. Boldt J, Mueller M, Kuhn D, Linke LC, Hempelmann G: Circulating adhesion molecules in the critically ill: a comparison between trauma and sepsis patients. Intensive Care Medicine 1996, 22: 122–128.

    Article  PubMed  CAS  Google Scholar 

  18. Cowley HC, Heney D, Gearing AJH, Hemingway I, Webster NR: Increased circulating adhesion molecule concentrations in patients with the systemic inflammatory response syndrome: a prospective cohort study. Critical Care Medicine 1994, 22: 651–657.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgery/Intensive Care Unit, Helsinki University Central Hospital, Haartmaninkatu 4, 00290, Helsinki, Finland

    M. Hynninen & O. Takkunen

  2. Department of Medicine/Division of Infectious Diseases, Helsinki University Central Hospital, Haartmaninkatu 4, 00290, Helsinki, Finland

    M. Valtonen

  3. Department of Clinical Chemistry, Helsinki University Central Hospital, Haartmaninkatu 4, 00290, Helsinki, Finland

    M. Vaara & P. Kuusela

  4. Children's Hospital, Helsinki University Central Hospital, Haartmaninkatu 4, 00290, Helsinki, Finland

    H. Markkanen

  5. Department of Bacteriology and Immunology, Helsinki University, Haartmaninkatu 3, 00290, Helsinki, Finland

    M. Hynninen & H. Saxen

Authors
  1. M. Hynninen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Valtonen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Vaara
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. H. Markkanen
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. P. Kuusela
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. H. Saxen
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. O. Takkunen
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hynninen, M., Valtonen, M., Vaara, M. et al. Plasma interleukin-8, interleukin-10, and E-selectin levels in neutropenic and non-neutropenic bacteremic patients. Eur. J. Clin. Microbiol. Infect. Dis. 16, 587–591 (1997). https://doi.org/10.1007/BF02447921

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02447921

Keywords

Search

Navigation