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RETRACTED ARTICLE: Circulating adhesion molecules in the critically ill: A comparison between trauma and sepsis patients

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This article was retracted on 04 April 2023

This article has been updated

Abstract

Objective

The time course of circulating adhesion molecules was monitored in traumatized and sepsis patients.

Design

Prospective, descriptive.

Setting

A surgical intensive care unit of a university hospital.

Patients

A total of 30 consecutive critically ill patients suffering either from trauma (n=15) or postoperative sepsis (n=15).

Interventions

All patients were on continuous analgo-sedation and mechanical ventilation.

Measurements and results

From arterial blood samples, plasma levels of soluble adhesion molecules [endothelial leukocyte adhesion molecules (sELAM-1), intercellular adhesion molecule-1 (sICAM-1)], and vascular cell adhesion molecule-1 (sVCAM-1) were measured on the day of admission (trauma patients) or on the day of diagnosis of sepsis (=baseline values), and during the following 5 days. In the trauma group,sELAM-1 (57.9±11.0 ng/ml) andsVCAM-1 (698±93 ng/ml) were within normal ranges at baseline, whereas they were markedly elevated in the sepsis group (sELAM-1: 340±95 ng/ml;sVCAM-1; 1,042±449 ng/ml). In the sepsis patients,sELAM-1 significantly decreased andsVCAM-1 increased, but remained almost unchanged in the trauma patients. Non-survivors showed markedly elevated plasma levels ofsELAM-1 andsVCAM-1.sICAM-1 was elevated in both groups at baseline and was higher in the sepsis group (1,266±261 ng/ml) than in the trauma group. In the septic patients,sICAM-1 increased further (2,022±609 ng/ml) and remained unchanged in the trauma group. All non-survivors showedsICAM-1 plasma levels of >800 ng/ml.

Conclusion

Endothelial damage may result in multiple-organ dysfunction syndrome. Adhesion molecules are considered to be a cornerstone in this process. Trauma patients showed lower plasma levels of circulating adhesion molecules than did sepsis patients indicating more pronounced (inflammatory related) endothelial activation or damage in sepsis. Therapeutic modulation of circulating adhesion molecules may be of benefit to the patients outcome and therefore warrants further study.

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References

  1. Fowler AA, Fisher BJ, Centor RM, Carchman RA (1984) Development of the adult respiratory distress syndrome: progressive alterations of neutrophil chemotactic and secretory process. Am J Pathol 116: 427–435

    CAS  PubMed  PubMed Central  Google Scholar 

  2. Stoolman LM (1993) Adhesion molecules involved in leukocyte recruitment and lymphocyte recirculation. Chest 103 [Suppl]: 79S-86S

    Article  CAS  PubMed  Google Scholar 

  3. Paulson JC (1991) Selectin/carbohydrate-mediated adhesion of leukocytes. In: Harlan JM, Liu DY (eds) Adhesion: its role in inflammatory disease. Freeman, New York, pp 19–42

    Google Scholar 

  4. Cotran RS, Pober HS (1988) Endothelial activation. Its role in inflammatory immune reactions. In: Simionescu N, Simionescu M (eds) Endothelial cell biology. Plenum Press, New York, pp 335–347

    Chapter  Google Scholar 

  5. Harlan JM (1987) Neutrophil-mediated vascular injury. Acta Med Scand [Suppl] 715: 123–129

    CAS  Google Scholar 

  6. Osborn L (1990) Leukocyte adhesion to endothelium in inflammation. Cell 62:3–6

    Article  CAS  PubMed  Google Scholar 

  7. Weiss SJ (1989) Tissue destruction by neutrophils. N Engl J Med 320: 365–376

    Article  CAS  PubMed  Google Scholar 

  8. Engler FL, Dahlgren MD, Morris D, Peterson MA, Schmid-Schoenbein G (1991) Role of leukocytes in the response to acute myocardial ischemia and reflow in dogs. Am J Physiol 251: H314-H323

    Google Scholar 

  9. Verrier ED, Shen I (1993) Potential role of neutrophil anti-adhesion therapy in myocardial stunning, myocardial infarction, and organ dysfunction after cardiopulmonary bypass. J Card Surg 8 [Suppl]: 309–312

    Article  CAS  PubMed  Google Scholar 

  10. Springer TA (1990) Adhesion receptors of the immune system. Nature 346: 425–434

    Article  CAS  PubMed  Google Scholar 

  11. Lawrence MB, Springer TA (1991) Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequisite for adhesion through integrins. Cell 65: 1–20

    Article  Google Scholar 

  12. Rothlein R, Mainolfi EA, Czajkowski M, Marlin SD (1991) A form of circulating ICAM-1 in human serum. J Immunol 147:3788–3793

    Article  CAS  PubMed  Google Scholar 

  13. Ballantyne CE, Mainolfi JB, Young NT (1992) Prognostic value of increased levels of circulating intercellular adhesion molecules-1 after heart transplantation. Clin Res 39: 285a

    Google Scholar 

  14. Gearing AJH, Newman W (1993) Circulating adhesion molecules in disease. Immunol Today 14: 506–512

    Article  CAS  PubMed  Google Scholar 

  15. Baker SP, O Neill B (1976) The injury severity score: an update. J Trauma 16: 882–888

    Article  CAS  PubMed  Google Scholar 

  16. Members of the American college of chest physicians/society of critical care medicine conference committee (1992) American college of chest physicians/society of critical care medicine consensus conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 20: 864–874

    Article  Google Scholar 

  17. Murray JF, Matthay MA, Luce JM, Flick MR (1988) An expanded definition of the adult respiratory distress syndrome. Am Rev Respir Dis 138: 720–723

    Article  CAS  PubMed  Google Scholar 

  18. Mariscalco MM (1993) Leukocytes and the inflammatory response. Crit Care Med 21: S347–348

    Article  Google Scholar 

  19. Williams TJ, Hellewell PG (1992) Endothelial cell biology. Am Rev Respir Dis 146: S45-S50

    Article  CAS  PubMed  Google Scholar 

  20. Elices MJ, Osborn L, Takada Y, Crouse C, Luhowskyj S, Hemler ME, Lobb RR (1990) VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at the site distinct from the VLA-4/fibronectin binding site. Cell 60: 577–584

    Article  CAS  PubMed  Google Scholar 

  21. Hammer DA, Apte SM (1992) Simulation of cell rolling and adhesion on surfaces in shear flow: general results and analysis of selectin-mediated neutrophil adhesion. Biophys J 63: 35–57

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Pelletier RP, Ohye RG, Vanbuskirk A, Sedmak DD, Kincade P, Ferguson RM, Orosz CG (1992) Importance of endothelial VCAM-1 for inflammatory leukocytic infiltration in vivo. J Immunol 149: 2473–2481

    Article  CAS  PubMed  Google Scholar 

  23. Ma XI, Tsao PS, Viehamn GE, Lefer AM (1991) Antibody to CD-18 exerts endothelial and cardioprotective effects on myocardial ischemia and reperfusion. J Clin Invest 88: 1237–1243

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Winn RK, Vedder NB, Mihelcic D, Flaherty LC, Landale L, Harlan (1993) The role of adhesion molecules in reperfusion injury. In: Boney RJ (ed) Inflammatory disease therapy. Agents and actions (AAS) 41. Birkhäuser, Basel, pp S113-S122

    Google Scholar 

  25. Kayal S, Guerot E, Rezgui MN, Aissa F, Simmonet M, Labousse J (1994) Elevated levels of circulating ICAM-I and E-selectin in the plasma of patients with severe sepsis syndrome. Intensive Care Med 20 [Suppl 1]: S26

    Google Scholar 

  26. Newman W, Beall LD, Carson CW, Hunder CG, Graben N, Randhawa ZI, Gopal TV, Wiener-Kronish J, Matthay MA (1993) Soluble E-selectin is found in supernatants of activated endothelial cells and is elevated in the serum of patients with septic shock. J Immunol 150: 633–654

    Article  Google Scholar 

  27. Cowley HC, Heney D, Gearing AJH, Hemingway I, Webster NR (1994) Increased circulating adhesion molecule concentrations in patients with septic inflammatory response: a prospective cohort study. Crit Care Med 22: 651–657

    Article  CAS  PubMed  Google Scholar 

  28. Tschaikowsky K, Sittl R, Braun GG, Hering W, Rügheimer E (1993) Increased fMet-Leu-Phe receptor expression and altered superoxide production of neutrophil granulocytes in septic and posttraumatic patients. Clin Investig 72: 18–25

    Article  PubMed  Google Scholar 

  29. Redl H, Dinges HP, Buurman WA, van der Linden CJ, Pober JS, Cotran RS, Schlag G (1991) Expression of endothelial leucocyte adhesion molecule-1 in septic but not traumatic/hypovolemic shock in the baboon. Am J Pathol 139: 461–466

    CAS  PubMed  PubMed Central  Google Scholar 

  30. Babcock GF, White-Owen C (1994) Impaired expression of Fc receptors and adhesion molecules on neutrophils following thermal and other traumatic injuries, the effects of GM & G-CSF. Intensive Care Med 20 [Suppl 1]: S102

    Google Scholar 

  31. Palluy O, Morliere L, Gris JC, Bonne C, Modat G (1992) Hypoxia/reoxygenation stimulates endothelium to promote neutrophil adhesion. Free Radic Biol Med 13: 21–30

    Article  CAS  PubMed  Google Scholar 

  32. Chaudry IH, Ayala A (1993) Immune consequences of hypovolemic shock and resuscitation. Curr Opin Anesth 6: 385–392

    Article  Google Scholar 

  33. Yamazaki M, Asakura H, Sato T, Tsugawa Y, Matsumura M, Kawamura Y, Ohka T, Matsuda T (1992) Changes in plasma levels of thrombomodulin during haemodialysis. Blood Coagul Fibrinolysis 3: 113–117

    Article  CAS  PubMed  Google Scholar 

  34. Sakurabayashi I, Itou S, Ishii H (1985) Studies on granulocyte elastase in plasma. Jpn J Clin Hematol 33: 1113–1118

    CAS  Google Scholar 

  35. Lobb R, Chi-Rosso G, Leone DR, Leone DR, Rosa MD, Bixler S, Newman BM, Luhowskyj S (1991) Expression and functional characterization of a soluble form of endothelial-leucocyte adhesion molecule-1. J Immunol 147: 24–129

    Article  Google Scholar 

  36. Spertinini O, Kansas GS, Munro JM, Griffin JD, Tedder TF (1991) Regulation of lekocyte migration by activation of leukocyte adhesion molecule-1 (LMA-1) selectin. Nature 349: 691–694

    Article  Google Scholar 

  37. Weissmann G (1989) The role of neutrophils in vascular injury: a summary of signal transduction mechanisms in cell/cell interactions. Springer Semin Immunopathol 1: 235–243

    Google Scholar 

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Authors and Affiliations

  1. Klinikum der Stadt Ludwigshafen, Anesthesiology and Intensive Care Medicine, Bremserstr. 79, D-67063, Ludwigshafen, Germany

    J. Boldt

  2. Department of Anesthesiology and, Intensive Care Medicine, Justus-Liebig-University, Giessen Klinikstr. 29, D-35392, Giessen, Germany

    M. Müller, D. Kuhn, L. C. Linke & G. Hempelmann

Authors
  1. J. Boldt
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  2. M. Müller
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  3. D. Kuhn
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  4. L. C. Linke
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  5. G. Hempelmann
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Boldt, J., Müller, M., Kuhn, D. et al. RETRACTED ARTICLE: Circulating adhesion molecules in the critically ill: A comparison between trauma and sepsis patients. Intensive Care Med 22, 122–128 (1996). https://doi.org/10.1007/BF01720718

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  • DOI: https://doi.org/10.1007/BF01720718

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