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On-line thermal monitoring of aspartic acid separation in a high voidage ion-exchange column at high flow rate

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Biotechnology Techniques

Abstract

A simple thermal monitoring technique has been successfully applied to an adsorption system using a novel ion exchanger with a large internal void volume (voidage) which can be operated at high superficial velocity (SV). Temperature changes resulting from heats of adsorption could be followed effectively using semi-conductor thermistor devices inserted into the resin through the column wall. Results show that, despite the high feed rates adopted, the thermal signals generated can be consistently related to the position of the breakthrough front within the bed.

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Yang, M., Ming, F., Hubble, J. et al. On-line thermal monitoring of aspartic acid separation in a high voidage ion-exchange column at high flow rate. Biotechnol Tech 6, 409–412 (1992). https://doi.org/10.1007/BF02447479

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  • DOI: https://doi.org/10.1007/BF02447479

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