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Reactions of the immune and hemopoietic systems to antigenic stimulation in the cytostatic disease

  • Oncology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

A single intraperitoneal injection of cyclophosphamide in the maximum tolerated dose to male CBA mice followed by immunization with thymus-dependent antigen suppressed the humoral immunity reactions (the number of antibody-producing splenocytes and their functional activity) and hematological parameters at the early stages of the cytostatic disease, this suppression persisting at the late stages of the disease.

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Authors and Affiliations

  1. Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences, Tomsk

    N. V. Masnaya & G. M. Ratner

  2. Siberian Medical University, Tomsk

    N. V. Masnaya & G. M. Ratner

Authors
  1. N. V. Masnaya
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  2. G. M. Ratner
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 11, pp. 576–578, November, 1998

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Masnaya, N.V., Ratner, G.M. Reactions of the immune and hemopoietic systems to antigenic stimulation in the cytostatic disease. Bull Exp Biol Med 126, 1152–1154 (1998). https://doi.org/10.1007/BF02447260

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  • DOI: https://doi.org/10.1007/BF02447260

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