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Participation of Endogenous dilation factor of the adrenals in hypotensive effect of indapamide

  • Pharmacology and Toxicology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The effect of indapamide on neurogenic constrictor responses was examined in an isolated segment of rat tail artery perfused by blood from intact rats and rats with surgically removed adrenal medulla. It was found that adrenal demedullation abolishes reduction in neurogenic constrictor responses of the arterial segment observed under the effect of indapamide.

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Authors and Affiliations

  1. Department of Human and Animal Physiology, Biological Faculty, Moscow, USSR

    N. A. Medvedeva & M. A. Nesterova

  2. Department of Pharmacology, Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University, Moscow, USSR

    O. S. Medvedev

Authors
  1. N. A. Medvedeva
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  2. M. A. Nesterova
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  3. O. S. Medvedev
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 11, pp. 365–368, November, 1998

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Medvedeva, N.A., Nesterova, M.A. & Medvedev, O.S. Participation of Endogenous dilation factor of the adrenals in hypotensive effect of indapamide. Bull Exp Biol Med 126, 1144–1146 (1998). https://doi.org/10.1007/BF02447257

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  • DOI: https://doi.org/10.1007/BF02447257

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